Immunology Research Center, Tabriz University of Medical Sciences, ZIP Code 15731 Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, ZIP Code 15731 Tabriz, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, ZIP Code 15731 Tabriz, Iran; Drug Applied Research Centre, Tabriz University of Medical Sciences, ZIP Code 15731 Tabriz, Iran.
Int Immunopharmacol. 2021 Feb;91:107331. doi: 10.1016/j.intimp.2020.107331. Epub 2021 Jan 5.
The present review provides an overview of recent advances regarding the function of Th17 cells and their produced cytokines in the progression of viral diseases. Viral infections alone do not lead to virus-induced malignancies, as both genetic and host safety factors are also involved in the occurrence of malignancies. Acquired immune responses, through the differentiation of Th17 cells, form the novel components of the Th17 cell pathway when reacting with viral infections all the way from the beginning to its final stages. As a result, instead of inducing the right immune responses, these events lead to the suppression of the immune system. In fact, the responses from Th17 cells during persistent viral infections causes chronic inflammation through the production of IL-17 and other cytokines which provide a favorable environment for tumor growth and its development. Additionally, during the past decade, these cells have been understood to be involved in tumor progression and metastasis. However, further research is required to understand Th17 cells' immune mechanisms in the vast variety of viral diseases. This review aims to determine the roles and effects of the immune system, especially Th17 cells, in the progression of viral diseases; which can be highly beneficial for the diagnosis and treatment of these infections.
本综述概述了 Th17 细胞及其产生的细胞因子在病毒疾病进展中的功能的最新进展。病毒感染本身并不会导致病毒引起的恶性肿瘤，因为遗传和宿主安全因素也参与了恶性肿瘤的发生。获得性免疫反应通过 Th17 细胞的分化，在与病毒感染的反应中从开始到最后阶段形成 Th17 细胞途径的新组成部分。结果，这些事件并没有诱导正确的免疫反应，而是导致免疫系统受到抑制。事实上，持续的病毒感染期间 Th17 细胞的反应通过产生 IL-17 和其他细胞因子引起慢性炎症，为肿瘤生长和发展提供了有利的环境。此外，在过去十年中，这些细胞已被理解参与肿瘤的进展和转移。然而，需要进一步的研究来了解 Th17 细胞在各种病毒疾病中的免疫机制。本综述旨在确定免疫系统，特别是 Th17 细胞在病毒疾病进展中的作用和影响；这对于这些感染的诊断和治疗非常有帮助。
