Samad Navira, Nguyen Hanh H, Scott David, Ebeling Peter R, Milat Frances
Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.
Department of Endocrinology, Monash Health, Clayton, Victoria, Australia.
Semin Reprod Med. 2020 Sep;38(4-05):277-288. doi: 10.1055/s-0040-1721797. Epub 2021 Jan 8.
Accelerated bone loss and muscle decline coexist in women with premature ovarian insufficiency (POI), but there are significant gaps in our understanding of musculoskeletal health in POI. This article is the first of a two-part review which describes estrogen signaling in muscle and its role in musculoskeletal health and disease. Current evidence regarding the utility of available diagnostic tests and therapeutic options is also discussed. A literature review from January 2000 to March 2020 was conducted to identify relevant studies. Women with POI experience significant deterioration in musculoskeletal health due to the loss of protective effects of estrogen. In addition to bone loss, muscle decay and dysfunction is now increasingly recognized. Nevertheless, there is a paucity of validated tools to assess muscle parameters. There is a growing need to acknowledge bone-muscle codependence to design new therapies which target both muscle and bone, resulting in improved physical performance and reduced morbidity and mortality. More high-quality research and international collaborations are needed to address the deficiencies in our understanding and management of musculoskeletal health in women with POI.
卵巢早衰（POI）女性存在骨质流失加速和肌肉衰退并存的情况，但我们对POI患者肌肉骨骼健康的了解仍存在重大差距。本文是一篇分为两部分的综述中的第一篇，描述了雌激素在肌肉中的信号传导及其在肌肉骨骼健康和疾病中的作用。还讨论了有关现有诊断测试和治疗选择效用的当前证据。我们进行了一项从2000年1月至2020年3月的文献综述，以确定相关研究。由于雌激素保护作用丧失，POI女性的肌肉骨骼健康状况显著恶化。除了骨质流失外，肌肉衰退和功能障碍现在也越来越受到认可。然而，缺乏经过验证的评估肌肉参数的工具。越来越需要认识到骨骼与肌肉的相互依存关系，以设计针对肌肉和骨骼的新疗法，从而改善身体机能并降低发病率和死亡率。需要更多高质量的研究和国际合作来弥补我们在理解和管理POI女性肌肉骨骼健康方面的不足。
