Department of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.
Department of Endocrinology, Monash Health, Clayton, VIC, Australia.
Climacteric. 2021 Oct;24(5):481-490. doi: 10.1080/13697137.2021.1917539. Epub 2021 May 6.
Premature ovarian insufficiency (POI), defined as a loss of ovarian function before the age of 40 years, is a life-changing diagnosis that has numerous long-term consequences. Musculoskeletal complications, including osteoporosis and fractures, are a key concern for women with POI. The risk of bone loss is influenced by the underlying etiology of POI, and the degree and duration of estrogen deficiency. A decline in muscle mass as a result of estrogen and androgen deficiency may contribute to skeletal fragility, but has not been examined in women with POI. This article aims to review musculoskeletal health in POI; summarize the traditional and novel modalities available to screen for skeletal fragility and muscle dysfunction; and provide updated evidence for available management strategies.
卵巢早衰（POI）定义为 40 岁以前卵巢功能丧失，这是一个改变生活的诊断，会带来许多长期后果。骨骼肌肉并发症，包括骨质疏松症和骨折，是 POI 患者的主要关注点。骨质流失的风险受 POI 的潜在病因、雌激素缺乏的程度和持续时间影响。由于雌激素和雄激素缺乏导致的肌肉质量下降可能导致骨骼脆弱，但尚未在 POI 女性中进行研究。本文旨在回顾 POI 的骨骼肌肉健康；总结现有的传统和新型方法来筛查骨骼脆弱和肌肉功能障碍；并提供现有管理策略的最新证据。
