Braun T I, Fekete T, Lynch A
Department of Medicine, Temple University Health Sciences Center, Philadelphia, PA 19140.
Arch Intern Med. 1988 Mar;148(3):634-6.
A serologic and epidemiologic survey was undertaken to explain the high incidence of eosinophilia (14.1%) in nine of 64 residents of a facility for mentally retarded adults in Pennsylvania. Seven residents had antibodies to Strongyloides stercoralis as determined by an IgG enzyme-linked immunosorbent assay system (10.9%) and five (71.4%) of this subset had persistent eosinophilia, suggesting a strong association. Sex, race, age, ward, degree of retardation, and medication were not associated with eosinophilia. Stool examination revealed S stercoralis larvae in two residents with S stercoralis antibodies and eosinophilia. Follow-up studies after thiabendazole treatment of the residents with S stercoralis antibodies showed resolution of eosinophilia and disappearance of S stercoralis antibodies in most. Eosinophilia in an adult institutional setting may be associated with strongyloidiasis, even in a nonendemic area. The enzyme-linked immunosorbent assay for antibody to S stercoralis may be useful in diagnosing or monitoring therapy of strongyloidiasis.
进行了一项血清学和流行病学调查，以解释宾夕法尼亚州一家成年智障者机构64名居民中有9人（14.1%）嗜酸性粒细胞增多症发病率较高的原因。通过IgG酶联免疫吸附测定系统确定，7名居民有抗粪类圆线虫抗体（10.9%），该亚组中有5人（71.4%）持续嗜酸性粒细胞增多，提示有密切关联。性别、种族、年龄、病房、智障程度和用药情况与嗜酸性粒细胞增多症无关。粪便检查发现，两名有抗粪类圆线虫抗体且嗜酸性粒细胞增多的居民中有粪类圆线虫幼虫。对有抗粪类圆线虫抗体的居民用噻苯达唑治疗后的随访研究显示，大多数人的嗜酸性粒细胞增多症得到缓解，抗粪类圆线虫抗体消失。即使在非流行地区，成年机构环境中的嗜酸性粒细胞增多症也可能与类圆线虫病有关。检测抗粪类圆线虫抗体的酶联免疫吸附测定可能有助于诊断或监测类圆线虫病的治疗。
