De Palo Micaela, Scicchitano Pietro, Malvindi Pietro Giorgio, Paparella Domenico
Section of Cardiac Surgery, A.O.U. Consorziale Policlinico di Bari, 70124 Bari, Italy.
Section of Cardiology, F. Perinei Hospital, Altamura, 70022 Bari, Italy.
Antibiotics (Basel). 2021 Jan 6;10(1):50. doi: 10.3390/antibiotics10010050.
The interventional treatment of aortic stenosis is currently based on transcatheter aortic valve implantation/replacement (TAVI/TAVR) and surgical aortic valve replacement (SAVR). Prosthetic valve infective endocarditis (PVE) is the most worrisome complication after valve replacement, as it still carries high mortality and morbidity rate. Studies have not highlighted the differences in the occurrence of PVE in SAVR as opposed to TAVR, but the reported incidence rates are widely uneven. Literature portrays different microbiological profiles for SAVR and TAVR PVE: Staphylococcus, Enterococcus, and Streptococcus are the pathogens that are more frequently involved with differences regarding the timing from the date of the intervention. Imaging by means of transoesophageal echocardiography, and computed tomography (CT) Scan is essential in identifying vegetations, prosthesis dysfunction, dehiscence, periannular abscess, or aorto-ventricular discontinuity. In most cases, conservative medical treatment is not able to prevent fatal events and surgery represents the only viable option. The primary objectives of surgical treatment are radical debridement and the removal of infected tissues, the reconstruction of cardiac and aortic morphology, and the restoration of the aortic valve function. Different surgical options are discussed. Fast diagnosis, the adequacy of antibiotics treatment, and prompt interventions are essential in preventing the negative consequences of infective endocarditis (IE).
目前,主动脉瓣狭窄的介入治疗主要基于经导管主动脉瓣植入/置换术(TAVI/TAVR)和外科主动脉瓣置换术(SAVR)。人工瓣膜感染性心内膜炎(PVE)是瓣膜置换术后最令人担忧的并发症,因为其死亡率和发病率仍然很高。研究尚未突出SAVR与TAVR在PVE发生率上的差异,但报告的发病率差异很大。文献描述了SAVR和TAVR-PVE不同的微生物学特征:金黄色葡萄球菌、肠球菌和链球菌是更常涉及的病原体,在干预日期后的时间方面存在差异。通过经食管超声心动图和计算机断层扫描(CT)扫描进行成像对于识别赘生物、人工瓣膜功能障碍、裂开、瓣周脓肿或主动脉-心室连续性中断至关重要。在大多数情况下,保守药物治疗无法预防致命事件,手术是唯一可行的选择。手术治疗的主要目标是彻底清创和清除感染组织、重建心脏和主动脉形态以及恢复主动脉瓣功能。文中讨论了不同的手术选择。快速诊断、抗生素治疗的充分性以及及时干预对于预防感染性心内膜炎(IE)的负面后果至关重要。