Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.
Division of Rheumatology, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil.
Adv Rheumatol. 2021 Jan 8;61(1):1. doi: 10.1186/s42358-020-00157-1.
Modifiable cardiovascular risk factors (MCRFs), such as those related to aerobic capacity, muscle strength, physical activity, and body composition, have been poorly studied in Takayasu arteritis (TAK). Therefore, the aim of the study was to investigate MCRFs and their relationships with disease status and comorbidities among patients with TAK.
A multicenter cross-sectional study was conducted between 2019 and 2020, in which 20 adult women with TAK were compared with 16 healthy controls matched by gender, age, and body mass index. The following parameters were analyzed: aerobic capacity by cardiopulmonary test; muscle function by timed-stands test, timed up-and-go test, and handgrip test; muscle strength by one-repetition maximum test and handgrip test; body composition by densitometry; physical activity and metabolic equivalent by IPAQ, quality of life by HAQ and SF-36; disease activity by ITAS2010 and NIH score; and presence of comorbidities.
Patients with TAK had a mean age of 41.5 (38.0-46.3) years, disease duration of 16.0 (9.5-20.0) years, and a mean BMI of 27.7±4.5 kg/m. Three out of the 20 patients with TAK had active disease. Regarding comorbidities, 16 patients had systemic arterial hypertension, 11 had dyslipidemia, and two had type 2 diabetes mellitus, while the control group had no comorbidities. TAK had a significant reduction in aerobic capacity (absolute and relative VO peak), muscle strength in the lower limbs, increased visceral adipose tissue, waist-to-hip ratio, reduced walking capacity, decreased weekly metabolic equivalent, and quality of life (P< 0.05) as compared to controls. However, there were no correlations between these MCRFs parameters and disease activity.
TAK show impairment in MCRFs; therefore, strategies able to improve MCRF should be considered in this disease.
可改变的心血管危险因素（MCRFs），如与有氧能力、肌肉力量、身体活动和身体成分相关的因素，在 Takayasu 动脉炎（TAK）中研究甚少。因此，本研究旨在调查 TAK 患者的 MCRFs 及其与疾病状态和合并症的关系。
这是一项在 2019 年至 2020 年间进行的多中心横断面研究，纳入 20 名成年女性 TAK 患者与 16 名性别、年龄和体重指数匹配的健康对照者进行比较。分析以下参数：心肺测试评估有氧能力；定时站立测试、计时起立行走测试和握力测试评估肌肉功能；一次重复最大测试和握力测试评估肌肉力量；密度仪评估身体成分；国际体力活动问卷（IPAQ）评估身体活动和代谢当量；HAQ 和 SF-36 评估生活质量；ITAS2010 和 NIH 评分评估疾病活动；并评估合并症的存在。
TAK 患者的平均年龄为 41.5（38.0-46.3）岁，患病时间为 16.0（9.5-20.0）年，平均 BMI 为 27.7±4.5kg/m²。20 名 TAK 患者中有 3 名患者疾病处于活动期。在合并症方面，16 名患者患有系统性动脉高血压，11 名患者患有血脂异常，2 名患者患有 2 型糖尿病，而对照组无合并症。与对照组相比，TAK 患者的有氧能力（绝对和相对 VO 峰值）、下肢肌肉力量、内脏脂肪组织增加、腰臀比增加、步行能力下降、每周代谢当量减少和生活质量降低（P<0.05）。然而，这些 MCRFs 参数与疾病活动之间没有相关性。
TAK 患者的 MCRFs 受损；因此，应考虑在该疾病中采用改善 MCRFs 的策略。
