J Biomed Nanotechnol. 2020 Sep 1;16(9):1325-1358. doi: 10.1166/jbn.2020.2976.
In recent years, considerable achievements have been made to motivate the construction of tumor microenvironment (TME)-specific functional nanomaterials, which can effectively respond to the inherent pathological and physicochemical conditions in diseased regions to improve the specificity of imaging and drug delivery. Until now, various nanoarchitectures have been designed to combat cancer effectively and specifically. This review summarizes the latest developments in TME-specific theranostic nanoplatforms based on multifunctional nanomaterials that hold potential for achieving the targeted recognition at tumor sites. Recent progress and achievements have also been summarized for nanosystems that can specifically respond to the TME with various stimulus-responsive strategies and their applications for drug delivery, diagnosis, treatment, and synergistic theranostics of cancer. This review emphasizes the significance of functional nanomaterials in response to tumor stimuli to enhance anticancer treatment efficiency and facilitate development in extensive research fields, including nanoscience, biomedicine, and clinical applications.
近年来，在激发肿瘤微环境（TME）特异性功能纳米材料的构建方面取得了相当大的成就，这些材料能够有效地响应病变区域固有的病理和物理化学条件，提高成像和药物输送的特异性。到目前为止，已经设计了各种纳米结构来有效地、有针对性地治疗癌症。这篇综述总结了基于多功能纳米材料的 TME 特异性诊疗纳米平台的最新发展，这些平台有可能实现肿瘤部位的靶向识别。还总结了最近在能够通过各种刺激响应策略特异性响应 TME 的纳米系统方面的进展和成就，以及它们在药物输送、诊断、治疗和癌症协同治疗方面的应用。本综述强调了功能纳米材料在响应肿瘤刺激以提高抗癌治疗效率方面的重要性，并促进了纳米科学、生物医学和临床应用等广泛研究领域的发展。
