Zubenko G S, Moossy J, Hanin I, Martinez A J, Rao G R, Kopp U
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213.
Arch Neurol. 1988 Mar;45(3):255-9. doi: 10.1001/archneur.1988.00520270029016.
The specific activities of the cholinergic enzymes, choline acetyltransferase and acetylcholinesterase, as well as the density of muscarinic binding sites, were determined in five corresponding left and right regions of 16 brains obtained at autopsy from patients with histologically confirmed Alzheimer's disease. While a significant proportion of the individual specimens exhibited left-right asymmetries in cholinergic deficits, bilateral symmetry was the rule for frontal and temporal cortex, basal nucleus, and the prosubiculum of the hippocampus. In contrast to these four regions, left-right asymmetries in choline acetyltransferase activity and muscarinic receptor density appeared to be typical in the entorhinal cortex of the hippocampus.
在16例经组织学确诊为阿尔茨海默病的患者尸检获得的大脑中，对五个相应的左右脑区的胆碱能酶（胆碱乙酰转移酶和乙酰胆碱酯酶）的比活性以及毒蕈碱结合位点的密度进行了测定。虽然相当一部分个体标本在胆碱能缺陷方面表现出左右不对称，但额叶和颞叶皮质、基底核以及海马旁回前部的双侧对称是常态。与这四个区域不同，海马旁嗅皮质中胆碱乙酰转移酶活性和毒蕈碱受体密度的左右不对称似乎很典型。
