阿尔茨海默病中的无名质：胆碱能标记酶的组织化学和生物化学研究

The substantia innominata in Alzheimer's disease: an histochemical and biochemical study of cholinergic marker enzymes.

作者信息

Rossor M N, Svendsen C, Hunt S P, Mountjoy C Q, Roth M, Iversen L L

出版信息

Neurosci Lett. 1982 Feb 12;28(2):217-22. doi: 10.1016/0304-3940(82)90155-0.

Abstract

Acetylcholinesterase staining was examined in the substantia innominata of 3 normal human brains. Large intensely stained neurones were seen within the region of the basal nucleus of Meynert which is believed to be the origin of the cholinergic projection to the neocortex in animals. On the basis of the acetylcholinesterase staining pattern, the substantia innominata was dissected from post-mortem brain tissue of 19 cases of Alzheimer's disease (AD) and 16 controls so as to include the basal nucleus. Choline acetyltransferase (ChAT) activity was found to be reduced in the substantia innominata and amygdala in AD but not in the adjacent lentiform nucleus and hypothalamus.

摘要

对3个正常人类大脑的无名质进行了乙酰胆碱酯酶染色检查。在迈内特基底核区域可见大量染色强烈的神经元，该区域被认为是动物向新皮质胆碱能投射的起源。根据乙酰胆碱酯酶染色模式，从19例阿尔茨海默病（AD）患者和16例对照者的死后脑组织中分离出无名质，以包括基底核。发现AD患者无名质和杏仁核中的胆碱乙酰转移酶（ChAT）活性降低，但相邻的豆状核和下丘脑未降低。