Anderson A J, Sobocinski K A, Freedman D S, Barboriak J J, Rimm A A, Gruchow H W
Milwaukee Cardiovascular Data Registry, Medical College of Wisconsin, Milwaukee 53226.
Arteriosclerosis. 1988 Jan-Feb;8(1):88-94. doi: 10.1161/01.atv.8.1.88.
The relation of body fat distribution as measured by the ratio of waist to hip circumferences (WHR) to plasma levels of lipids and lipoproteins was studied in 713 men and 520 women who were employed by two Milwaukee companies. Quetelet index (kg/m2), waist girth, hip girth, and WHR were each positively related to levels of total cholesterol, triglycerides, apolipoprotein B, and the ratio of total to high density lipoprotein (HDL) cholesterol. In addition, the anthropometric measures were inversely associated with levels of HDL cholesterol. (Controlling for age, alcohol intake, exercise level, current smoking status, and oral contraceptive use only slightly reduced the strength of the correlations.) In addition, WHR and Quetelet Index were independently related to lipid and lipoprotein levels, and the magnitudes of the associations were roughly equivalent. For example, the mean (covariate-adjusted) triglyceride level among men in the upper tertile of the Quetelet Index was 37 mg/dl higher than for men in the lower tertile of the Quetelet Index; the corresponding difference according to WHR tertiles (upper to lower) was 39 mg/dl (p less than 0.01 for both effects). These findings indicate that in healthy men and women a less favorable lipid and lipoprotein profile is associated with elevated levels of both Quetelet Index and WHR.
在受雇于密尔沃基两家公司的713名男性和520名女性中，研究了通过腰臀围比（WHR）测量的身体脂肪分布与血脂和脂蛋白水平之间的关系。体重指数（kg/m²）、腰围、臀围和WHR均与总胆固醇、甘油三酯、载脂蛋白B水平以及总胆固醇与高密度脂蛋白（HDL）胆固醇的比值呈正相关。此外，人体测量指标与HDL胆固醇水平呈负相关。（控制年龄、酒精摄入量、运动水平、当前吸烟状况和口服避孕药的使用只会略微降低相关性的强度。）此外，WHR和体重指数与脂质和脂蛋白水平独立相关，且关联程度大致相当。例如，体重指数处于上三分位数的男性中，经协变量调整后的平均甘油三酯水平比体重指数处于下三分位数的男性高37mg/dl；根据WHR三分位数（上至下）的相应差异为39mg/dl（两种效应的p值均小于0.01）。这些发现表明，在健康男性和女性中，较差的脂质和脂蛋白谱与体重指数和WHR升高有关。
