Colebunders R, Francis H, Mann J M, Bila K M, Kandi K, Lebughe I, Gigase P, Van Marck E, Macher A M, Quinn T C
Project Syndrome d'ImmunoDeficit Acquit, Department of Public Health, Kinshasa, Zaire.
Arch Otolaryngol Head Neck Surg. 1988 Mar;114(3):330-2. doi: 10.1001/archotol.1988.01860150112027.
In Europe and in the United States, bilateral parotid gland swelling has been observed as a sign of human immunodeficiency virus (HIV) infection in children, but it has not been associated with HIV infection in adults. We observed a chronic parotid gland swelling in nine HIV-seropositive patients during a nine-month period in Kinshasa, Zaire. Parotid gland enlargement was bilateral in seven patients (78%), slightly painful in seven patients (78%), and painless in two patients (22%). No evidence of inflammation was observed around Stensen's duct. One of the two patients in whom a parotid gland biopsy was performed had a malignant lymphoma of the large-cell, histiocytic type. In the other patient, the parotid gland showed normal morphology with minor inflammation. Among 284 adults and 40 children with symptomatic HIV infection, chronic parotid gland enlargement was observed in none of the patients. However, two (0.7%) of the adults presented with an acute pyogenic parotitis. Further studies are needed to determine whether parotid gland enlargement is associated with HIV infection.
在欧洲和美国，双侧腮腺肿大已被视作儿童感染人类免疫缺陷病毒（HIV）的迹象，但在成人中尚未发现其与HIV感染有关。在扎伊尔金沙萨的九个月期间，我们观察到9例HIV血清反应阳性患者出现慢性腮腺肿大。7例患者（78%）腮腺肿大为双侧性，7例患者（78%）有轻微疼痛，2例患者（22%）无疼痛。在斯滕森导管周围未观察到炎症迹象。接受腮腺活检的2例患者中，1例患有大细胞组织细胞型恶性淋巴瘤。另1例患者的腮腺形态正常，有轻微炎症。在284例有症状的成人HIV感染者和40例有症状的儿童HIV感染者中，未观察到有慢性腮腺肿大的患者。然而，2例（0.7%）成人出现急性化脓性腮腺炎。需要进一步研究以确定腮腺肿大是否与HIV感染有关。
