Wittenborn J R
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):153S-156S. doi: 10.1111/j.1365-2125.1977.tb05743.x.
Two studies are reviewed, one in depressed patients, the other in healthy volunteers. The effect of nomifensine and imipramine on depressed out-patients has been studied in a controlled double-blind manner. Treatment lasted for 4 weeks and assessments were carried out before and at weekly intervals during the study. These involved use of a self-rating scale and four observer rating scales. In the self-rating scale, 13 of the 14 discriminating items favoured nomifensine, and indicated that it possessed a strengthening or energizing activity, and analysis of individual items on the Hamilton Depression Scale confirmed this. In this study, imipramine showed greater effect on mood and on sleep disturbances. A comparison of nomifensine, imipramine and placebo was carried out in 90 volunteers in a double-blind randomized study. Each volunteer received three doses of medication during the study day. The assessments include a Digit Symbol Substitution Test, the production of a temporal interval, and a simple and a complex test of attention or vigilance. The influence of nomifensine on these tests could not be distinguished from that of placebo. There was evidence, however, that imipramine depressed performance and possessed a sedative effect. The results of both studies, when considered together, are essentially in agreement.
本文回顾了两项研究，一项针对抑郁症患者，另一项针对健康志愿者。已采用对照双盲方式研究了诺米芬辛和丙咪嗪对门诊抑郁症患者的疗效。治疗持续4周，在研究期间于治疗前及每周进行评估。评估包括使用一份自评量表和四份观察者评定量表。在自评量表中，14个区分项目中的13项支持诺米芬辛，并表明它具有增强或提神作用，对汉密尔顿抑郁量表各单项的分析证实了这一点。在这项研究中，丙咪嗪对情绪和睡眠障碍显示出更大的疗效。在一项双盲随机研究中，对90名志愿者进行了诺米芬辛、丙咪嗪和安慰剂的比较。每位志愿者在研究日接受三剂药物。评估包括数字符号替换测试、时间间隔生成以及一项简单和一项复杂的注意力或警觉性测试。诺米芬辛对这些测试的影响与安慰剂无法区分。然而，有证据表明丙咪嗪会降低表现并具有镇静作用。两项研究的结果综合考虑后基本一致。
