Merideth C H, Feighner J P, Hendrickson G
J Clin Psychiatry. 1984 Apr;45(4 Pt 2):73-7.
Nomifensine, imipramine, and placebo were compared in 61 depressed geriatric outpatients over a 35-day period. At average daily doses of 150 mg, nomifensine and imipramine were significantly more effective than placebo in reducing symptoms of depression in this sample of elderly depressed patients. Nomifensine and imipramine were generally comparable in clinical effect; 78% of the nomifensine-treated patients were rated as improved at the end of treatment as compared with 64% of imipramine and 20% of placebo patients. The findings suggest a more favorable side effect profile for nomifensine, which was associated with a lower frequency of sedating and anticholinergic effects than was seen in the imipramine group.
在35天的时间里，对61名老年门诊抑郁症患者比较了诺米芬辛、丙咪嗪和安慰剂的疗效。在该老年抑郁症患者样本中，诺米芬辛和丙咪嗪的平均日剂量为150毫克，在减轻抑郁症状方面显著优于安慰剂。诺米芬辛和丙咪嗪的临床效果总体相当；治疗结束时，78%接受诺米芬辛治疗的患者被评定为病情改善，相比之下，接受丙咪嗪治疗的患者为64%，接受安慰剂治疗的患者为20%。研究结果表明，诺米芬辛的副作用情况更为有利，与丙咪嗪组相比，其镇静和抗胆碱能作用的发生率较低。
