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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):237S-241S. doi: 10.1111/j.1365-2125.1977.tb05759.x.

Double-blind controlled comparisons of nomifensine with placebo, imipramine, desipramine, viloxazine, nortriptyline, a combination of amitriptyline and chlordiazepoxide, and diazepam have been carried out in various parts of the world. 2. Dosage ranged from 50-225 mg daily, and treatment lasted from 2-26 weeks. 3. Nomifensine was shown to possess useful antidepressive activity, to counteract inhibition, to restore drive and to relieve anxiety. 4. Adverse reactions were uncommon, particularly anticholinergic effects, and nomifensine was not shown to cause sedation or to interact with alcohol. No withdrawal phenomena were observed after 6 months' treatment. 5. Nomifensine is not suitable for severely agitated patients.

世界上不同地区已对诺米芬辛与安慰剂、丙咪嗪、地昔帕明、维洛沙嗪、去甲替林、阿米替林与氯氮卓的复方制剂以及地西泮进行了双盲对照比较。2. 剂量范围为每日50 - 225毫克，治疗持续2 - 26周。3. 诺米芬辛显示具有有效的抗抑郁活性，可对抗抑制作用，恢复动力并缓解焦虑。4. 不良反应不常见，尤其是抗胆碱能作用，且未显示诺米芬辛会引起镇静作用或与酒精相互作用。治疗6个月后未观察到戒断现象。5. 诺米芬辛不适用于严重躁动的患者。

Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):237S-241S. doi: 10.1111/j.1365-2125.1977.tb05759.x.

Double-blind controlled comparisons of nomifensine with placebo, imipramine, desipramine, viloxazine, nortriptyline, a combination of amitriptyline and chlordiazepoxide, and diazepam have been carried out in various parts of the world. 2. Dosage ranged from 50-225 mg daily, and treatment lasted from 2-26 weeks. 3. Nomifensine was shown to possess useful antidepressive activity, to counteract inhibition, to restore drive and to relieve anxiety. 4. Adverse reactions were uncommon, particularly anticholinergic effects, and nomifensine was not shown to cause sedation or to interact with alcohol. No withdrawal phenomena were observed after 6 months' treatment. 5. Nomifensine is not suitable for severely agitated patients.

世界上不同地区已对诺米芬辛与安慰剂、丙咪嗪、地昔帕明、维洛沙嗪、去甲替林、阿米替林与氯氮卓的复方制剂以及地西泮进行了双盲对照比较。2. 剂量范围为每日50 - 225毫克，治疗持续2 - 26周。3. 诺米芬辛显示具有有效的抗抑郁活性，可对抗抑制作用，恢复动力并缓解焦虑。4. 不良反应不常见，尤其是抗胆碱能作用，且未显示诺米芬辛会引起镇静作用或与酒精相互作用。治疗6个月后未观察到戒断现象。5. 诺米芬辛不适用于严重躁动的患者。