拓展 IKK 的视野：新底物和新生物学。
Expanding the View of IKK: New Substrates and New Biology.
机构信息
Department of Surgery, Division of Surgical Oncology, and The Hellen Diller Comprehensive Cancer Center, The University of California San Francisco, San Francisco, CA, USA.
Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Trends Cell Biol. 2021 Mar;31(3):166-178. doi: 10.1016/j.tcb.2020.12.003.
The inhibitor of kappa B kinase (IKK) family consists of IKKα, IKKβ, and the IKK-related kinases TBK1 and IKKε. These kinases are considered master regulators of inflammation and innate immunity via their control of the transcription factors NF-κB, IRF3, and IRF7. Novel phosphorylated substrates have been attributed to these kinases, a subset of which is not directly related to either inflammation or innate immunity. These findings have greatly expanded the perspectives on the biological activities of these kinases. In this review we highlight some of the novel substrates for this kinase family and discuss the biological implications of these phosphorylation events.
IKK 激酶（IKK）家族由 IKKα、IKKβ、以及 IKK 相关激酶 TBK1 和 IKKε组成。这些激酶通过控制转录因子 NF-κB、IRF3 和 IRF7，被认为是炎症和先天免疫的主要调节剂。这些激酶已经被归因于一些新的磷酸化底物，其中一部分与炎症或先天免疫没有直接关系。这些发现极大地扩展了人们对这些激酶的生物学活性的认识。在这篇综述中，我们强调了这个激酶家族的一些新的底物，并讨论了这些磷酸化事件的生物学意义。
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