犬体内8-甲氧基补骨脂素不同制剂的生物利用度研究。

Study of the bioavailability of different formulations of 8-methoxypsoralen in the dog.

作者信息

Monbaliu J G, Belpaire F M, Bogaert M G

机构信息

Heymans Institute of Pharmacology, University of Gent Medical School, Belgium.

出版信息

Biopharm Drug Dispos. 1988 Jan-Feb;9(1):1-8. doi: 10.1002/bod.2510090102.

DOI:10.1002/bod.2510090102

PMID:3342281

Abstract

The absolute bioavailability of 8-methoxypsoralen in gelatin capsules and as a solution was studied in dogs. A dose of 2 mg kg-1 was given. Both for the solution and the gelatin capsules, a large variation in bioavailability was found between the different dogs. For the gelatin capsules in 1 dog out of 4 an absolute bioavailability of more than 100 per cent was found; for the solution a bioavailability of more than 100 per cent was found in all 4 dogs. Resorption was more rapid and bioavailability higher for the solution than for the gelatin capsules. Relative bioavailability of an emulsion and of a solution of 8-methoxypsoralen was studied in 2 dogs. A faster resorption and a higher bioavailability were found for the solution.

摘要

在犬类中研究了8-甲氧基补骨脂素在明胶胶囊中的绝对生物利用度及其溶液剂的绝对生物利用度。给予剂量为2mg/kg-1。无论是溶液剂还是明胶胶囊，不同犬之间的生物利用度均存在很大差异。对于明胶胶囊，4只犬中有1只的绝对生物利用度超过100%；对于溶液剂，所有4只犬的生物利用度均超过100%。溶液剂的吸收比明胶胶囊更快，生物利用度更高。在2只犬中研究了8-甲氧基补骨脂素乳剂和溶液剂的相对生物利用度。溶液剂的吸收更快，生物利用度更高。