Zhuang Hui, Lin Rongcai, Liu Yaqin, Zhang Meng, Zhai Dong, Huan Zhiguang, Wu Chengtie
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People's Republic of China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, People's Republic of China.
ACS Biomater Sci Eng. 2019 Dec 9;5(12):6725-6734. doi: 10.1021/acsbiomaterials.9b01095. Epub 2019 Nov 22.
For the postoperative treatment of bone cancer, biomaterials should possess an antitumor effect and simultaneous repair ability of bone defects. Compared with single photothermal treatment or magnetothermal treatment, photo/magnetothermal joint treatment represents a more high-efficient strategy to kill tumor cells. In this work, a 3D-printed bioceramic scaffold with a photo/magnetothermal effect was successfully designed and fabricated, which exhibited the function of killing tumor cells and excellent osteogenic bioactivity, via incorporating an Fe element into akermanite (AKT) bioceramics. After doping with ferric elements, the AKT scaffolds possessed significantly enhanced compressive strength and desirable ferromagnetic property. The ferric elements endowed the AKT scaffolds with excellent photo/magnetothermal effects, and hence the scaffolds could efficiently kill tumor cells in vitro under mild laser power density and magnetic field. In addition, the Fe-doped AKT bioceramic scaffolds significantly promoted cell proliferation and osteogenic differentiation of rabbit bone mesenchymal stem cells as compared with the original AKT scaffolds without Fe elements. The results suggest that Fe-doped bioceramic scaffolds with both photo/magnetothermal effect and in vitro osteogenic bioactivity could be a promising biomaterial for the synergistic therapy of bone cancers.
对于骨癌的术后治疗，生物材料应具备抗肿瘤作用以及同时修复骨缺损的能力。与单一的光热治疗或磁热治疗相比，光/磁热联合治疗是一种更高效的杀死肿瘤细胞的策略。在这项工作中，通过将铁元素掺入镁黄长石（AKT）生物陶瓷中，成功设计并制造了具有光/磁热效应的3D打印生物陶瓷支架，该支架具有杀死肿瘤细胞的功能和优异的成骨生物活性。掺入铁元素后，AKT支架的抗压强度显著提高，并具有理想的铁磁性。铁元素赋予AKT支架优异的光/磁热效应，因此该支架在温和的激光功率密度和磁场条件下能够在体外有效杀死肿瘤细胞。此外，与不含铁元素的原始AKT支架相比，掺铁的AKT生物陶瓷支架显著促进了兔骨髓间充质干细胞的增殖和成骨分化。结果表明，具有光/磁热效应和体外成骨生物活性的掺铁生物陶瓷支架有望成为一种用于骨癌协同治疗的生物材料。
