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[翻译后修饰与子宫内膜异位症的研究进展]

[Advances in Post-translational Modifications and Endometriosis].

作者信息

Zhu Jing Wen, Xue Qing

机构信息

Department of Gynecology and Obstetrics,Peking University First Hospital,Beijing 100034,China.

出版信息

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020 Dec 30;42(6):810-814. doi: 10.3881/j.issn.1000-503X.11427.

Abstract

Proteins exert their roles in life activities via post-translational modifications(PTMs),which include phosphorylation,acetylation,ubiquitination,glycosylation,and methylation.These modifications can change the functions of proteins and play key roles in a variety of diseases.Endometriosis is a common disease in women of childbearing age,although its molecular mechanisms remain unclear.Recent studies have shown that PTMs may be involved in the pathogenesis of endometriosis.Here we review the roles of PTMs in the occurrence and development of endometriosis and the potential medical treatments.

摘要

蛋白质通过翻译后修饰(PTM)在生命活动中发挥作用,这些修饰包括磷酸化、乙酰化、泛素化、糖基化和甲基化。这些修饰可以改变蛋白质的功能,并在多种疾病中起关键作用。子宫内膜异位症是育龄期女性的常见疾病,但其分子机制尚不清楚。最近的研究表明,翻译后修饰可能参与子宫内膜异位症的发病机制。在此,我们综述翻译后修饰在子宫内膜异位症发生发展中的作用以及潜在的医学治疗方法。

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