Neuro and Vascular Guidance, Buchmann Institute for Molecular Life Sciences (BMLS) and Institute of Cell Biology and Neuroscience, Max-von-Laue-Strasse 15, D-60438, Frankfurt am Main, Germany; Cardio-Pulmonary Institute (CPI), Max-von-Laue-Strasse 15, D-60438, Frankfurt am Main, Germany.
Neuro and Vascular Guidance, Buchmann Institute for Molecular Life Sciences (BMLS) and Institute of Cell Biology and Neuroscience, Max-von-Laue-Strasse 15, D-60438, Frankfurt am Main, Germany.
Trends Neurosci. 2021 May;44(5):393-405. doi: 10.1016/j.tins.2020.12.002. Epub 2021 Jan 7.
The blood-brain barrier (BBB) is a dynamic platform for exchange of substances between the blood and the brain parenchyma, and it is an essential functional gatekeeper for the central nervous system (CNS). While it is widely recognized that BBB disruption is a hallmark of several neurovascular pathologies, an aspect of the BBB that has received somewhat less attention is the dynamic modulation of BBB tightness to maintain brain homeostasis in response to extrinsic environmental factors and physiological changes. In this review, we summarize how BBB integrity adjusts in critical stages along the life span, as well as how BBB permeability can be altered by common stressors derived from nutritional habits, environmental factors and psychological stress.
血脑屏障（BBB）是血液和脑实质之间物质交换的动态平台，是中枢神经系统（CNS）的重要功能守门员。虽然众所周知，BBB 破坏是几种神经血管病理学的标志，但 BBB 的一个方面受到的关注较少，即 BBB 紧密性的动态调节，以维持大脑内环境稳定，以应对外在环境因素和生理变化。在这篇综述中，我们总结了 BBB 完整性如何在整个生命周期的关键阶段进行调整，以及 BBB 通透性如何通过源自营养习惯、环境因素和心理压力的常见应激源改变。
