Aix Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Aix Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Trends Immunol. 2021 Feb;42(2):120-136. doi: 10.1016/j.it.2020.12.006. Epub 2021 Jan 8.
The human body contains dozens of endocrine and exocrine glands, which regulate physiological processes by secreting hormones and other factors. Glands can be subdivided into contiguous tissue modules, each consisting of an interdependent network of cells that together perform particular tissue functions. Among those cells are macrophages, a diverse type of immune cells endowed with trophic functions. In this review, we discuss recent findings on how resident macrophages support tissue modules within glands via the creation of mutually beneficial cell-cell circuits. A better comprehension of gland macrophage function and local control within their niche is essential to achieve a refined understanding of gland physiology in homeostasis and disease.
人体包含数十种内分泌腺和外分泌腺，通过分泌激素和其他因子来调节生理过程。腺体可以细分为连续的组织模块，每个模块由相互依存的细胞网络组成，共同执行特定的组织功能。在这些细胞中，有巨噬细胞，一种具有营养功能的多样化免疫细胞。在这篇综述中，我们讨论了最近的发现，即驻留巨噬细胞如何通过创建互利的细胞-细胞电路来支持腺体中的组织模块。更好地理解腺体中巨噬细胞的功能和局部控制对于精细理解腺体在生理稳态和疾病中的功能至关重要。
