Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
The School of Veterinary Science, The University of Sydney, Sydney, NSW, Australia.
Vet Anaesth Analg. 2021 Mar;48(2):247-251. doi: 10.1016/j.vaa.2020.10.008. Epub 2020 Dec 15.
To compare the dose, cardiopulmonary effects and quality of anaesthetic induction in dogs using propofol (10 mg mL) and diluted propofol (5 mg mL).
Randomized, blinded, clinical study.
A total of 28 client-owned dogs (12 males/16 females).
Following intramuscular acepromazine (0.02 mg kg) and methadone (0.2 mg kg), propofol (UP, 10 mg mL) or diluted propofol (DP, 5 mg mL) was administered intravenously (0.2 mL kg minute) by an anaesthetist unaware of the allocated group to achieve tracheal intubation. Sedation, intubation and induction quality were scored from 0 to 3. Pre- and post-induction pulse rate (PR), respiratory rate (f) and systolic (SAP), mean (MAP) and diastolic (DAP) arterial blood pressure were compared. Time to first breath and induction dose were recorded. Data were analysed for normality and Mann-Whitney U or Student t tests were performed where appropriate. Significance was set at p < 0.05. Data are presented as mean ± standard deviation or median (range).
The propofol dose administered to achieve induction was lower in the DP group (2.62 ± 0.48 mg kg) than in the UP group (3.48 ± 1.17 mg kg) (p = 0.021). No difference was observed in pre- and post-induction PR, SAP, MAP, DAP and f between groups. The differences between post-induction and pre-induction values of these variables were also similar between groups. Time to first breath did not differ between groups. Sedation scores were similar between groups. Quality of tracheal intubation was marginally better with UP 0 (0-1) than with DP 1 (0-2) (p = 0.036), but overall quality of induction was similar between groups [UP 0 (0-1) and DP 0 (0-1), p = 0.549].
Diluting propofol reduced the dose to induce anaesthesia without significantly altering the cardiopulmonary variables.
比较使用 10mg/mL 丙泊酚和稀释的丙泊酚（5mg/mL）对犬进行麻醉诱导的剂量、心肺效应和麻醉诱导质量。
随机、双盲、临床研究。
28 只患犬（12 只雄性/16 只雌性）。
在肌肉注射氯丙嗪（0.02mg/kg）和美沙酮（0.2mg/kg）后，由一位不了解分组的麻醉师静脉注射丙泊酚（UP，10mg/mL）或稀释的丙泊酚（DP，5mg/mL）（0.2mL/kg·min），以达到气管插管。镇静、插管和诱导质量评分从 0 到 3 分。比较诱导前后的脉搏率（PR）、呼吸频率（f）和收缩压（SAP）、平均动脉压（MAP）和舒张压（DAP）。记录首次呼吸时间和诱导剂量。对数据进行正态性分析，适当情况下进行曼-惠特尼 U 检验或学生 t 检验。p＜0.05 为有统计学意义。数据以均数±标准差或中位数（范围）表示。
DP 组（2.62±0.48mg/kg）达到诱导所需的丙泊酚剂量低于 UP 组（3.48±1.17mg/kg）（p=0.021）。两组之间诱导前后的 PR、SAP、MAP、DAP 和 f 无差异。两组之间这些变量的诱导后与诱导前差值也相似。两组之间首次呼吸时间无差异。镇静评分两组之间相似。气管插管质量 UP0（0-1）稍优于 DP1（0-2）（p=0.036），但总体诱导质量两组相似[UP0（0-1）和 DP0（0-1），p=0.549]。
稀释丙泊酚可减少麻醉诱导所需的剂量，而不会显著改变心肺变量。
