Boveri Sarah, Brearley Jacqueline C, Dugdale Alexandra H A
Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK.
Vet Anaesth Analg. 2013 Sep;40(5):449-54. doi: 10.1111/vaa.12034. Epub 2013 Mar 28.
To determine if body condition score (BCS) influences the sedative effect of intramuscular (IM) premedication or the dose of intravenous (IV) propofol required to achieve endotracheal intubation in dogs.
Prospective clinical study.
Forty-six client-owned dogs undergoing general anaesthesia.
Dogs were allocated to groups according to their BCS (BCS, 1 [emaciated] to 9 [obese]): Normal-weight Group (NG, n = 25) if BCS 4-5 or Over-weight Group (OG, n = 21) if BCS over 6. Dogs were scored for sedation prior to IM injection of medetomidine (5 μg kg(-1) ) and butorphanol (0.2 mg kg(-1) ) and twenty minutes later anaesthesia was induced by a slow infusion of propofol at 1.5 mg kg(-1) minute(-1) until endotracheal intubation could be achieved. The total dose of propofol administered was recorded. Data were tested for normality then analyzed using Student t-tests, Mann-Whitney U tests, chi-square tests or linear regression as appropriate.
Mean ( ± SD) propofol requirement in NG was 2.24 ± 0.53 mg kg(-1) and in OG was 1.83 ± 0.36 mg kg(-1) . The difference between the groups was statistically significant (p = 0.005). The degree of sedation was not different between the groups (p = 0.7). Post-induction apnoea occurred in 11 of 25 animals in the NG and three of 21 in OG (p = 0.052).
Overweight dogs required a lower IV propofol dose per kg of total body mass to allow tracheal intubation than did normal body condition score animals suggesting that IV anaesthetic doses should be calculated according to lean body mass. The lower dose per kg of total body mass may have resulted in less post-induction apnoea in overweight/obese dogs. The effect of IM premedication was not significantly affected by the BCS.
Induction of general anaesthesia with propofol in overweight dogs may be expected at lower doses than normal-weight animals.
确定体况评分（BCS）是否会影响犬肌肉注射（IM）术前用药的镇静效果或气管插管所需的静脉注射（IV）丙泊酚剂量。
前瞻性临床研究。
46只接受全身麻醉的客户-owned犬。
根据犬的BCS（BCS，1[消瘦]至9[肥胖]）将犬分为几组：如果BCS为4 - 5，则为正常体重组（NG，n = 25）；如果BCS超过6，则为超重组（OG，n = 21）。在肌肉注射美托咪定（5μg kg⁻¹）和布托啡诺（0.2mg kg⁻¹）之前对犬进行镇静评分，20分钟后，以1.5mg kg⁻¹ 分钟⁻¹的速度缓慢输注丙泊酚诱导麻醉，直至成功进行气管插管。记录给予的丙泊酚总剂量。对数据进行正态性检验，然后根据情况使用Student t检验、Mann-Whitney U检验、卡方检验或线性回归进行分析。
NG组丙泊酚平均需求量（±标准差）为2.24 ± 0.53mg kg⁻¹，OG组为1.83 ± 0.36mg kg⁻¹。两组之间的差异具有统计学意义（p = 0.005）。两组之间的镇静程度无差异（p = 0.7）。诱导后呼吸暂停在NG组25只动物中有11只出现，OG组21只中有3只出现（p = 0.052）。
与正常体况评分的动物相比，超重犬每千克总体重所需的静脉注射丙泊酚剂量更低，以进行气管插管，这表明静脉麻醉剂量应根据瘦体重计算。每千克总体重较低的剂量可能导致超重/肥胖犬诱导后呼吸暂停较少。IM术前用药的效果未受到BCS的显著影响。
预计超重犬使用丙泊酚诱导全身麻醉时所需剂量低于正常体重动物。
