Department of Anatomy, Medical College of Taizhou University, Taizhou 317000, China; Department of Burn, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, China.
Department of Burn, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai 317000, China.
J Biosci Bioeng. 2021 Apr;131(4):341-347. doi: 10.1016/j.jbiosc.2020.11.010. Epub 2021 Jan 8.
Burn injury is one of the most common physical injuries in clinic. It is a big challenge to find an ideal treatment for burn injury. Mesenchymal stem cells (MSCs) have been suggested as a promising candidate for wound healing. However, it is critical to improve the therapeutic efficiency of MSCs for treatment of burn injury. Here, we demonstrated that overexpression of caveolin-1, the main component of the caveolae plasma membranes, promoted the proliferation of MSCs both in vitro and in vivo. Moreover, transplantation of MSCs overexpressing caveolin-1 facilitated the expression of various growth factors and immunoregulatory cytokines and accelerated deep second-degree burn wound healing in a rat model of burn injury. Our results suggest that overexpression of caveolin-1 can improve the therapeutic efficiency of MSCs, which may be a promising strategy for the treatment of deep second-degree burn injury in clinic.
烧伤是临床中最常见的物理损伤之一。寻找治疗烧伤的理想方法是一个巨大的挑战。间充质干细胞（MSCs）已被认为是一种有前途的伤口愈合候选物。然而，提高 MSCs 治疗烧伤的治疗效率至关重要。在这里，我们证明了窖蛋白-1（质膜小窝的主要成分）的过表达促进了 MSC 在体外和体内的增殖。此外，过表达窖蛋白-1 的 MSC 的移植促进了各种生长因子和免疫调节细胞因子的表达，并加速了大鼠深二度烧伤模型中深度二度烧伤创面的愈合。我们的结果表明，窖蛋白-1 的过表达可以提高 MSC 的治疗效率，这可能是临床治疗深二度烧伤的一种有前途的策略。
