Tonneau M, Lacornerie T, Mirabel X, Pasquier D
Département universitaire de radiothérapie, centre Oscar-Lambret, université de Lille, 3, rue Combemale, 59020 Lille cedex, France.
Service de physique médicale, centre Oscar-Lambret, 3, rue Combemale, 59020 Lille cedex, France.
Cancer Radiother. 2021 May;25(3):283-295. doi: 10.1016/j.canrad.2020.08.047. Epub 2021 Jan 7.
Stereotactic body radiation therapy (SBRT) for locally advanced pancreatic cancer (LAPC) is an emerging treatment option. Most studies showed local control of approximately 75% with no evidence of improved overall survival. Gastrointestinal toxicities could be significant, ranging up to 22% for acute toxicities≥grade 3+ and 44% for late toxicities≥grade 3+. Currently, no standardized guidelines for treatment and management scheme. We conducted a systemic review of published prospective and retrospective trials to evaluate the efficacy, safety, technical data, and discuss future directions.
立体定向体部放射治疗（SBRT）用于局部晚期胰腺癌（LAPC）是一种新兴的治疗选择。大多数研究显示局部控制率约为75%，但没有证据表明总生存期有所改善。胃肠道毒性可能很显著，3级及以上急性毒性高达22%，3级及以上晚期毒性高达44%。目前，尚无治疗和管理方案的标准化指南。我们对已发表的前瞻性和回顾性试验进行了系统评价，以评估其疗效、安全性、技术数据，并讨论未来方向。
