Rai Gaurav S, Maru Jayesh J
Department of Chemistry, University School of Sciences, Gujarat University, Navrangpura, Ahmedabad, 380009 India.
Chem Heterocycl Compd (N Y). 2020;56(12):1517-1522. doi: 10.1007/s10593-020-02844-9. Epub 2021 Jan 4.
This review summarizes diverse synthetic protocols for the preparation of pyrrolo[2,1-][1,2,4]triazine derivatives, covering literature sources from the past two decades. For effective representation, the synthetic methods toward the title compound are classified into six distinct categories: 1) synthesis from pyrrole derivatives, 2) synthesis bromohydrazone, 3) synthesis formation of triazinium dicyanomethylide, 4) multistep synthesis, 5) transition metal mediated synthesis, and 6) rearrangement of pyrrolooxadiazines. A brief outline of all optimized schemes is provided with relevant examples.
本综述总结了过去二十年来文献中用于制备吡咯并[2,1-][1,2,4]三嗪衍生物的各种合成方法。为了便于有效呈现，合成该标题化合物的方法分为六个不同类别：1）由吡咯衍生物合成；2）由溴腙合成；3）由三嗪二氰甲基化物形成合成；4）多步合成；5）过渡金属介导的合成；6）吡咯并恶二嗪的重排。文中提供了所有优化方案的简要概述及相关示例。
