Borg Rebecca, Pace David
Department of Paediatrics, Mater Dei Hospital, Msida, Malta.
J Infect Prev. 2020 Mar;21(2):68-71. doi: 10.1177/1757177419885009. Epub 2019 Nov 6.
Methicillin-resistant (MRSA) colonisation is a challenge in healthcare institutions worldwide. In this retrospective nation-wide study, the rates of MRSA colonisation and infection from 2012 to 2015, on the only neonatal and paediatric intensive care unit (NPICU) in the country, were determined. Mean local rates were compared to rates of MRSA colonisation reported in units in North America, Asia and Europe between 2001 and 2010. The average rate of MRSA colonisation on admission to NPICU from 2012 to 2015 was 3.71% (95% confidence interval [CI] 2.17-5.25), while the mean rate of acquired colonisation was 14.60% (95% CI 6.16-23.04). Both were significantly higher than in units abroad: 1.9% and 4.1%, respectively ( = 0.04 and < 0.001). There were no cases of invasive MRSA infection, while the mean rate of non-invasive infection was 0.77% (95% CI 0.54-1.01). Improved adherence to infection control measures and newer molecular diagnostic techniques are needed to further decrease the acquisition of MRSA.
耐甲氧西林金黄色葡萄球菌（MRSA）定植是全球医疗机构面临的一项挑战。在这项全国性回顾性研究中，确定了该国唯一一家新生儿及儿科重症监护病房（NPICU）2012年至2015年期间的MRSA定植率和感染率。将当地的平均发生率与2001年至2010年期间北美、亚洲和欧洲各病房报告的MRSA定植率进行了比较。2012年至2015年期间，NPICU入院时MRSA定植的平均发生率为3.71%（95%置信区间[CI]为2.17 - 5.25），而获得性定植的平均发生率为14.60%（95%CI为6.16 - 23.04）。两者均显著高于国外各病房的发生率：分别为1.9%和4.1%（P = 0.04和P < 0.001）。未发生侵袭性MRSA感染病例，而非侵袭性感染的平均发生率为0.77%（95%CI为0.54 - 1.01）。需要提高对感染控制措施的依从性并采用更新的分子诊断技术，以进一步减少MRSA的获得。
