Ehrmeyer S S, Laessig R H, Schell K
School of Allied Health Professions, Medical Technology Program, University of Wisconsin-Madison 53706.
Clin Chem. 1988 Feb;34(2):250-6.
Previous studies have documented the ineffectiveness of using either the group mean +/- 2 group standard deviations (SD) or the 1(2)s rule as the standard of acceptable performance in evaluating interlaboratory proficiency testing (PT) data. Using computer simulation of PT data, we evaluated the efficiency of 244 alternatives to the 1(2)s rule, all based on the PT population's mean and SD. Using the traditional interlaboratory PT format, we determined the ability of each rule to correctly identify both good and deficient intralaboratory performance. The rules are based on results from one to five PT samples "analyzed" at the same time. Because the effectiveness of the criteria set for acceptable performance in a PT program is influenced by the population SD, each rule's capabilities were examined for PT populations with interlaboratory SDs ranging from 1% through 10% of the population mean value. All rules achieve their maximum efficiency over a narrow range of interlaboratory SDs. For PT evaluations of intralaboratory performance to be optimally effective, selection of the rule must be based on the SD of the PT population.
以往研究已证明，在评估实验室间能力验证（PT）数据时，使用组均值±2组标准差（SD）或1(2)s规则作为可接受性能标准是无效的。通过对PT数据进行计算机模拟，我们评估了1(2)s规则的244种替代方法的有效性，所有替代方法均基于PT总体的均值和SD。采用传统的实验室间PT格式，我们确定了每条规则正确识别良好和不足的实验室内部性能的能力。这些规则基于同时“分析”的1至5个PT样本的结果。由于PT计划中设定的可接受性能标准的有效性受总体SD的影响，因此针对实验室间SD范围为总体均值的1%至10%的PT总体，检查了每条规则的能力。所有规则在实验室间SD的狭窄范围内实现其最大效率。为使实验室内部性能的PT评估达到最佳效果，规则的选择必须基于PT总体的SD。
