Dhruv Samyak, Polavarapu Abhishek, Gumaste Vivek
Internal Medicine, Staten Island University Hospital, Staten Island, USA.
Gastroenterology, Staten Island University Hospital, Staten Island, USA.
Cureus. 2020 Dec 5;12(12):e11915. doi: 10.7759/cureus.11915.
The incidence of infection (CDI) has been decreasing in the last decade, though the incidence of community-acquired CDI has remained stable. In an elderly patient on Coumadin®, we report an unexpected decrease in international normalized ratio (INR) during the treatment of second recurrence of CDI treated with fidaxomicin. According to the available information, fidaxomicin does not interfere with warfarin. However, in this case, warfarin effects diminished, and only with increased dosage therapeutic INR was achieved.
在过去十年中，艰难梭菌感染（CDI）的发病率一直在下降，尽管社区获得性CDI的发病率保持稳定。在一名服用华法林的老年患者中，我们报告了在用非达霉素治疗CDI第二次复发期间国际标准化比值（INR）意外下降的情况。根据现有信息，非达霉素不会干扰华法林。然而，在这种情况下，华法林的作用减弱，只有增加剂量才能达到治疗性INR。
