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右美托咪定联合地塞米松用于跟腱修复术中收肌管/腘窝神经阻滞延长镇痛效果的研究

Use of Dexmedetomidine With Dexamethasone for Extended Pain Relief in Adductor Canal/Popliteal Nerve Block During Achilles Tendon Repair.

作者信息

Kassem Hisham, Urits Ivan, Viswanath Omar, Kaye Alan D, Eskander Jonathan P

机构信息

Anesthesiology and Perioperative Medicine, Mount Sinai Medical Center, Miami Beach, USA.

Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.

出版信息

Cureus. 2020 Dec 5;12(12):e11917. doi: 10.7759/cureus.11917.

Abstract

The use of regional anesthetic techniques in the peri-operative period has increased as a means to improve analgesia and patient outcomes. Traditionally, various local anesthetics are used and addition of adjuncts such as epinephrine, clonidine, and dexamethasone has shown to prolong the block effect. There has been ongoing research to support the prolongation of a regional block with the addition of dexamethasone and dexmedetomidine (Dex-Dex), providing analgesia for multiple days. We present a case of a 35-year-old female who underwent an Achilles tendon repair with an adductor/popliteal nerve block. Both dexmedetomidine and dexamethasone were added to the local anesthetic mixture with substantial postoperative analgesic control. The patient also did not require any supplemental opioid medication. This case emphasizes the proposed synergistic effect of dexmedetomidine and dexamethasone when added to the local anesthesia injectate for lower extremity peripheral nerve blocks.

摘要

围手术期区域麻醉技术的应用有所增加,作为改善镇痛效果和患者预后的一种手段。传统上,会使用各种局部麻醉剂,添加肾上腺素、可乐定和地塞米松等辅助药物已显示可延长阻滞效果。一直在进行研究以支持通过添加地塞米松和右美托咪定(右美托咪定-地塞米松)来延长区域阻滞时间,从而提供多日镇痛。我们报告一例35岁女性患者,她接受了跟腱修复术,并采用了内收肌/腘神经阻滞。右美托咪定和地塞米松均添加到局部麻醉混合液中,术后镇痛效果良好。患者也无需任何补充性阿片类药物。该病例强调了右美托咪定和地塞米松添加到局部麻醉注射液中用于下肢周围神经阻滞时所提议的协同效应。

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Adjunct medications for peripheral and neuraxial anesthesia.辅助外周神经和椎管内麻醉的药物。
Best Pract Res Clin Anaesthesiol. 2018 Jun;32(2):83-99. doi: 10.1016/j.bpa.2018.06.011. Epub 2018 Jul 3.
7
Dexamethasone as an adjuvant to peripheral nerve block.地塞米松作为外周神经阻滞的辅助药物。
Cochrane Database Syst Rev. 2017 Nov 9;11(11):CD011770. doi: 10.1002/14651858.CD011770.pub2.

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