Hegde Vishwajit, Shekar Nidhi, Garrett Filip, Baz Maher, Anstead Michael
Internal Medicine, University of Kentucky College of Medicine, Lexington, USA.
Pediatrics, Marshall University, Huntington, USA.
Cureus. 2020 Dec 6;12(12):e11935. doi: 10.7759/cureus.11935.
Pregabalin is a gamma-aminobutyric acid (GABA) derivative that was commercially approved by the Food and Drug Administration (FDA) in 2004. It is commonly used in the treatment of diabetic neuropathy, peripheral neuropathy, and spinal cord injury. We present the case of a 36-year-old Caucasian male double lung transplant recipient who presented with an 18-month history of fatigue and muscle weakness. He had elevated creatinine kinase level and his muscle biopsy showed evidence of drug-induced myopathy that improved after the cessation of pregabalin. We present a case of drug-induced myopathy as a rare complication of pregabalin therapy in a double lung transplant recipient.
普瑞巴林是一种γ-氨基丁酸（GABA）衍生物，于2004年获得美国食品药品监督管理局（FDA）的商业批准。它常用于治疗糖尿病性神经病变、周围神经病变和脊髓损伤。我们报告一例36岁的白种男性双肺移植受者，他有18个月的疲劳和肌肉无力病史。他的肌酸激酶水平升高，肌肉活检显示有药物性肌病的证据，停用普瑞巴林后病情有所改善。我们报告一例双肺移植受者因普瑞巴林治疗引起的罕见并发症——药物性肌病。
