Falsaperla Raffaele, Sortino Vincenzo, Collotta Ausilia Desiree, Grassi Patrizia, Vaccalluzzo Marco Simone, Pulvirenti Alfredo, Gambilonghi Francesco, Ruggieri Martino
Neonatal Intensive Care Unit, San Marco Hospital, University Hospital Policlinico "G. Rodolico-San Marco", Catania, Italy.
Unit of Pediatrics and Pediatric Emergency, University Hospital Policlinico "G. Rodolico-San Marco", Catania, Italy.
Clin Exp Vaccine Res. 2024 Jul;13(3):225-231. doi: 10.7774/cevr.2024.13.3.225. Epub 2024 Jul 31.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) usually causes a mild disease in children and the most serious consequence is multisystem inflammatory syndrome in children (MIS-C). Currently, there are no data about the protective role of vaccination performed by parents on children regarding the development of MIS-C. The aim of our study is to establish whether parental vaccination is related to MIS-C and the protective value of SARS-CoV-2 vaccination performed by parents against the occurrence of MIS-C in their children.
Our retrospective single center study included 124 patients aged 1 month to 18 years admitted to emergency department from April 2020 to March 2022 for coronavirus disease 2019 disease.
Parental vaccination was negatively correlated with the development of MIS-C: 4% of patients with both parents vaccinated developed MIS-C, while patients with no parent vaccinated to have developed MIS-C were 20%.
Parental vaccination could be an important factor influencing the course of the disease and reduces the probability that a child would develop MIS-C by 83% if both parents vaccinated.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）通常在儿童中引起轻度疾病，最严重的后果是儿童多系统炎症综合征（MIS-C）。目前，尚无关于父母接种疫苗对儿童MIS-C发生发展的保护作用的数据。我们研究的目的是确定父母接种疫苗是否与MIS-C相关，以及父母接种SARS-CoV-2疫苗对其子女发生MIS-C的保护价值。
我们的回顾性单中心研究纳入了2020年4月至2022年3月因2019冠状病毒病入住急诊科的124例年龄在1个月至18岁的患者。
父母接种疫苗与MIS-C的发生呈负相关：父母双方都接种疫苗的患者中4%发生了MIS-C，而父母均未接种疫苗却发生MIS-C的患者为20%。
父母接种疫苗可能是影响疾病进程的一个重要因素，如果父母双方都接种疫苗，儿童发生MIS-C的概率可降低83%。
