Deform-nu：一种基于DNA变形能量的核小体定位预测器。
Deform-nu: A DNA Deformation Energy-Based Predictor for Nucleosome Positioning.
作者信息
Liu Guoqing, Zhao Hongyu, Meng Hu, Xing Yongqiang, Yang Hui, Lin Hao
机构信息
School of Life Sciences and Technology, Inner Mongolia University of Science and Technology, Baotou, China.
Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China.
出版信息
Front Cell Dev Biol. 2020 Dec 23;8:596341. doi: 10.3389/fcell.2020.596341. eCollection 2020.
The structure and function of chromatin can be regulated through positioning patterns of nucleosomes. DNA-based processes are regulated via nucleosomes. Therefore, it is significant to determine nucleosome positions in DNA-based processes. A deformation energy model was proposed to predict nucleosome positions in our previous study. A free web server based on the model (http://lin-group.cn/server/deform-nu/) was firstly established to estimate the occupancy and rotational positioning of nucleosomes in the study. Then, the performance of the model was verified by several examples. The results indicated that nucleosome positioning relied on the physical properties of DNA, such as deformation energy.
染色质的结构和功能可通过核小体的定位模式来调节。基于DNA的过程通过核小体进行调节。因此，在基于DNA的过程中确定核小体位置具有重要意义。在我们之前的研究中提出了一种变形能模型来预测核小体位置。在该研究中，首先基于该模型建立了一个免费的网络服务器（http://lin-group.cn/server/deform-nu/）来估计核小体的占有率和旋转定位。然后，通过几个例子验证了该模型的性能。结果表明，核小体定位依赖于DNA的物理性质，如变形能。
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