FineStr：一个用于单碱基分辨率核小体定位的网络服务器。
FineStr: a web server for single-base-resolution nucleosome positioning.
机构信息
Department of Computer Science, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.
出版信息
Bioinformatics. 2010 Mar 15;26(6):845-6. doi: 10.1093/bioinformatics/btq030. Epub 2010 Jan 26.
SUMMARY
The DNA in eukaryotic cells is packed into the chromatin that is composed of nucleosomes. Positioning of the nucleosome core particles on the sequence is a problem of great interest because of the role nucleosomes play in different cellular processes including gene regulation. Using the sequence structure of 10.4 base DNA repeat presented in our previous works and nucleosome core DNA sequences database, we have derived the complete nucleosome DNA bendability matrix of Caenorhabditis elegans. We have developed a web server named FineStr that allows users to upload genomic sequences in FASTA format and to perform a single-base-resolution nucleosome mapping on them.
AVAILABILITY
FineStr server is freely available for use on the web at http:/www.cs.bgu.ac.il/ approximately nucleom. The site contains a help file with explanation regarding the exact usage.
CONTACT
摘要
真核细胞中的 DNA 被包装到染色质中，而染色质是由核小体组成的。核小体核心颗粒在序列上的定位是一个非常有趣的问题，因为核小体在包括基因调控在内的不同细胞过程中发挥着重要作用。利用我们之前的工作中提出的 10.4 个碱基重复的序列结构和核小体核心 DNA 序列数据库，我们推导出了秀丽隐杆线虫完整的核小体 DNA 弯曲性矩阵。我们开发了一个名为 FineStr 的网络服务器，允许用户以 FASTA 格式上传基因组序列，并在其上进行单碱基分辨率的核小体作图。
可用性
FineStr 服务器可在网络上免费使用，网址为 http://www.cs.bgu.ac.il/approximately nucleom。该网站包含一个帮助文件，其中详细说明了确切的使用方法。
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