持续性新生儿高胰岛素血症
Persistent neonatal hyperinsulinism.
作者信息
Mathew P M, Young J M, Abu-Osba Y K, Mulhern B D, Hammoudi S, Hamdan J A, Sa'di A R
机构信息
Department of Paediatrics, Dhahran Health Center, Saudi Arabia.
出版信息
Clin Pediatr (Phila). 1988 Mar;27(3):148-51. doi: 10.1177/000992288802700307.
PMID:3342599
Abstract
Over a 3-year period, the diagnosis of persistent neonatal hyperinsulinism (PNH) was made in seven infants, from an unselected cohort of 18,726 births, all of Saudi Arabian origin. Thus the incidence of PNH was one in 2,675 births. The high incidence, associated consanguinity, and occurrence in siblings suggest that PNH may be inherited as an autosomal recessive disorder.
摘要
在3年时间里，从18726例出生婴儿（均为沙特阿拉伯血统）的非选择性队列中，诊断出7例持续性新生儿高胰岛素血症（PNH）。因此，PNH的发病率为每2675例出生中有1例。高发病率、相关的近亲结婚以及在兄弟姐妹中的发生表明，PNH可能作为常染色体隐性疾病遗传。
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