Wiweko Budi, Afdi Quamila Fahrizani, Harzif Achmad Kemal, Pratama Gita, Sumapradja Kanadi, Muharam Raden, Hestiantoro Andon, Zakirah Sarah Chairani
Human Reproductive, Infertility and Family Planning Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Int J Reprod Biomed. 2020 Dec 21;18(12):1065-1072. doi: 10.18502/ijrm.v18i12.8028. eCollection 2020 Dec.
Poor ovarian reserve and a high rate of pregnancy failure associated with low quality and quantity of oocytes are observed in poor responders to in vitro fertilization.
To assess the effect of age, body mass index (BMI), endometriosis, and history of ovarian surgery on ovarian reserve in a group of poor responders.
In this cross-sectional study 749 women who referred to Yasmin Clinic of Dr. Cipto Mangunkusumo National General Hospital from January 2013 to June 2017 were enrolled. Two definitions of poor responders and Poseidon criteria and consecutive sampling techniques were used. Participants were divided into good and poor responder groups based on the ovarian reserve test; participant with oocyte 3 was classified as a poor responder. Based on this, 188 participants with nine (4-47) oocytes were included in the poor responder group. While, good responder comprised of two (0-3) oocytes.
Age and anti-Mullerian hormone level (AMH) were significantly associated with ovarian reserve in the poor-responder group (p 0.001). However, in multivariate analyses, age was the only significant predictor of ovarian response in the poor-responder group (p = 0.004). While endometriosis was the significant predictor of Poseidon groups 1 and 4, surgical history was the significant predictor of Poseidon groups 2 and 3. Meanwhile, an increase in BMI decreased the risk of classification under Poseidon group 3.
Age, AMH, BMI, endometriosis, and history of ovarian surgery affected the risk of classification of the Poseidon group.
在体外受精反应不良者中观察到卵巢储备功能差以及与卵母细胞质量和数量低相关的高妊娠失败率。
评估年龄、体重指数（BMI）、子宫内膜异位症和卵巢手术史对一组反应不良者卵巢储备的影响。
在这项横断面研究中，纳入了2013年1月至2017年6月转诊至西托·曼古库苏莫国家综合医院亚斯敏诊所的749名女性。采用了反应不良者的两种定义、波塞冬标准和连续抽样技术。根据卵巢储备测试将参与者分为反应良好组和反应不良组；卵母细胞≤3个的参与者被归类为反应不良者。据此，反应不良组纳入了188名有9个（4 - 47个）卵母细胞的参与者。而反应良好组由有2个（0 - 3个）卵母细胞的参与者组成。
年龄和抗苗勒管激素水平（AMH）与反应不良组的卵巢储备显著相关（p < 0.001）。然而，在多变量分析中，年龄是反应不良组卵巢反应的唯一显著预测因素（p = 0.004）。虽然子宫内膜异位症是波塞冬1组和4组的显著预测因素，但手术史是波塞冬2组和3组的显著预测因素。同时，BMI的增加降低了在波塞冬3组下分类的风险。
年龄、AMH、BMI、子宫内膜异位症和卵巢手术史影响了波塞冬组分类的风险。
