Department of Otorhinolaryngology-Head and Neck Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.
Otolaryngology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Eur Arch Otorhinolaryngol. 2021 Nov;278(11):4279-4287. doi: 10.1007/s00405-020-06554-y. Epub 2021 Jan 11.
In the literature on stapes surgery, various materials have been used to seal the vestibulotomy. To date, there are only a few published randomized clinical trials with focus on hearing outcomes, using different sealing materials. Hence, the aim of this study was to compare hearing outcomes when using fat or Hyaluronic acid gel (HAG) to seal the stapedotomy.
The present double-blind, prospective, randomized clinical trial was conducted on ears undergoing stapedotomy in Dasthgheib Hospital, a referral otology center in Southern Iran, and Dena private hospital, Shiraz Iran. A total of 150 primary stapedotomies were evaluated, and sealing material was fat in 77 ears and HAG in 73.
60 (77.9%) of the fat group ears and 63 (86.3%) of the HAG group ears obtained postoperative air-bone gap (ABG) within 20 dB, but the difference was not significant (p = 0.182).
As a sealing material in stapedotomy, HAG is comparable with fat in terms of hearing outcomes. Therefore, HAG is recommended as a safe sealing material in stapedotomy.
在镫骨手术文献中，已经使用了各种材料来封闭前庭切开术。迄今为止，只有少数使用不同密封材料的关注听力结果的随机临床试验发表。因此，本研究旨在比较使用脂肪或透明质酸凝胶 (HAG) 密封镫骨术的听力结果。
本双盲、前瞻性、随机临床试验在伊朗南部的转诊耳科中心 Dasthgheib 医院和伊朗设拉子的 Dena 私立医院进行，共评估了 150 例初次镫骨切除术，77 例使用脂肪封闭，73 例使用 HAG。
脂肪组的 60 只（77.9%）和 HAG 组的 63 只（86.3%）术后气骨导差（ABG）在 20dB 以内，但差异无统计学意义（p=0.182）。
作为镫骨术的密封材料，HAG 在听力结果方面与脂肪相当。因此，HAG 被推荐为镫骨术的安全密封材料。
