Department of Ophthalmology, Duke University, Durham, NC, USA.
Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
Ocul Immunol Inflamm. 2022 Jul;30(5):1181-1185. doi: 10.1080/09273948.2020.1860233. Epub 2021 Jan 10.
To report two cases of microbial keratitis and/or endophthalmitis involving
Case series.
24-year-old female with a history of Herpes simplex virus 1 (HSV-1) and keratitis presented with a geographic epithelial defect and infiltrate in the left eye. Cultures were positive for HSV-1 and . Keratitis resolved with topical vancomycin and oral valacyclovir. A 65-year-old female with a history of type II diabetes and failed therapeutic penetrating keratoplasty presented with inferior corneal graft haze and vitreous inflammation of the right eye. Therapeutic penetrating keratoplasty and pars plana vitrectomy were performed, and the corneal button returned positive for . The patient was treated with topical and intravitreal vancomycin as well as topical and systemic steroids.
These cases expand the literature on keratitis and endophthalmitis and corroborate the role of steroid use and prior surgery as paramount risk factors.
报告两例涉及单纯疱疹病毒性角膜炎和/或眼内炎的病例。
病例系列。
一名 24 岁女性，有单纯疱疹病毒 1 型（HSV-1）和角膜炎病史，左眼出现地图状上皮缺损和浸润。培养物检测出 HSV-1 和 阳性。局部万古霉素和口服伐昔洛韦治疗后角膜炎缓解。一名 65 岁女性，有 II 型糖尿病病史和穿透性角膜移植失败史，右眼下方角膜移植混浊伴玻璃体炎症。行穿透性角膜移植和玻璃体切除术，角膜纽扣标本检测出 阳性。患者接受了局部和玻璃体内万古霉素以及局部和全身类固醇治疗。
这些病例扩展了关于单纯疱疹病毒性角膜炎和眼内炎的文献，并证实了类固醇使用和先前手术是主要的危险因素。
