Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, 414006, People's Republic of China.
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, People's Republic of China.
Top Curr Chem (Cham). 2021 Jan 11;379(1):5. doi: 10.1007/s41061-020-00319-1.
As we all know, organic phosphorus compounds have high application values in chemical industries. Compared with traditional compounds with P-X (X = Cl, Br, I) and P-H bonds, phosphorylation reagents containing P(O)-OH bonds are stable, environmentally friendly, and inexpensive. However, in recent years, there have been few studies on the selective functionalization of P(O)-OH bonds for the fabrication of P-C and P-Z bonds. In general, four-coordinated P(O)-OH compounds have reached coordination saturation due to the phosphorus atom center, but cannot evolve the phosphorus coordination center through intra-molecular tautomerization; however, the weak coordination effects between the P=O bond and transition metals can be utilized to activate P(O)-OH bonds. This review highlights the most important recent contributions toward the selective functionalization of P(O)-OH bonds via cyclization/cross coupling/esterification reactions using transition metals or small organic molecules as the catalyst.
众所周知，有机磷化合物在化学工业中有很高的应用价值。与传统的含 P-X（X=Cl、Br、I）和 P-H 键的化合物相比，含 P(O)-OH 键的磷酸化试剂稳定、环保且廉价。然而，近年来，关于 P(O)-OH 键的选择性功能化反应来构建 P-C 和 P-Z 键的研究较少。一般来说，由于磷原子中心，四配位的 P(O)-OH 化合物达到了配位饱和，但不能通过分子内互变异构来改变磷配位中心；然而，P=O 键和过渡金属之间的弱配位效应可以用来激活 P(O)-OH 键。本综述重点介绍了近年来利用过渡金属或小分子作为催化剂，通过环化/交叉偶联/酯化反应实现 P(O)-OH 键选择性功能化的最重要进展。
