Braun S A, Silling S, Schloer S M, Hofmann S C, Fritzen B, Oellig F, Lehmann P, Homey B, Assaf C, Emmert S, Fölster-Holst R, Tigges C, Wieland U, Kreuter A
Department of Dermatology, University Hospital Muenster, Muenster, Germany.
Department of Dermatology, Medical Faculty, Heinrich-Heine University, Duesseldorf, Germany.
J Eur Acad Dermatol Venereol. 2021 May;35(5):1219-1225. doi: 10.1111/jdv.17114. Epub 2021 Feb 5.
In contrast to adults, only limited data are available on the human papillomavirus (HPV)-type spectrum in anogenital warts (AGW) of children.
This study aimed to evaluate the HPV-type spectrum in AGW of prepubertal children.
MATERIALS & METHODS: In a retrospective German multicentre study, HPV genotyping was performed in AGW biopsies of 55 1- to 12-year-old children using HPV group-specific PCRs followed by hybridization with type-specific probes or sequence analysis.
Human papillomavirus-DNA was found in 53 of the 55 AGW. In 58.5% (31/53) of the HPV-positive AGW, mucosal HPV types were detected. HPV6 (27/53, 50.9%) was the predominant type. 43.4% (23/53) of the lesions were induced by cutaneous HPV types (HPV2, HPV27, HPV57). Mucosal HPV types were significantly more common in children under 5 years of age than in children 5 years of age and older (22/25, 88.0% [95% CI: 70.0-95.8] vs. 9/28, 32.1% [95% CI: 17.9-50.7], P < 0.001). In contrast, cutaneous HPV types were significantly more prevalent in the 5- to 12-year age group (4/25, 16.0% [95% CI 6.4-34.7] vs. 19/28, 67.9% [95% CI 49.3-82.1], P < 0.001).
Anogenital warts in 5- to 12-year-old children are frequently associated with cutaneous HPV types, possibly due to horizontal transmission. HPV typing, in addition to comprehensive clinical and psychosocial evaluation, can potentially help in the assessment of these cases.
与成人相比，关于儿童肛门生殖器疣（AGW）中人乳头瘤病毒（HPV）类型谱的数据有限。
本研究旨在评估青春期前儿童AGW中的HPV类型谱。
在一项回顾性德国多中心研究中，对55名1至12岁儿童的AGW活检组织进行HPV基因分型，采用HPV组特异性PCR，随后与型特异性探针杂交或进行序列分析。
55例AGW中有53例检测到HPV-DNA。在58.5%（31/53）的HPV阳性AGW中，检测到黏膜HPV类型。HPV6（27/53，50.9%）是主要类型。43.4%（23/53）的病变由皮肤HPV类型（HPV2、HPV27、HPV57）引起。黏膜HPV类型在5岁以下儿童中比5岁及以上儿童更常见（22/25，88.0% [95% CI：70.0 - 95.8] 对 9/28，32.1% [95% CI：17.9 - 50.7]，P < 0.001）。相比之下，皮肤HPV类型在5至12岁年龄组中更为普遍（4/25，16.0% [95% CI 6.4 - 34.7] 对 19/28，67.9% [95% CI 49.3 - 82.1]，P < 0.001）。
5至12岁儿童的肛门生殖器疣常与皮肤HPV类型相关，可能是由于水平传播。除了全面的临床和心理社会评估外，HPV分型可能有助于评估这些病例。
