Obalek S, Jablonska S, Favre M, Walczak L, Orth G
Department of Dermatology, Warsaw School of Medicine, Poland.
J Am Acad Dermatol. 1990 Aug;23(2 Pt 1):205-13. doi: 10.1016/0190-9622(90)70200-2.
To identify the papillomavirus types associated with condylomata acuminata in children and to evaluate their mode of transmission, we studied 32 children with anogenital warts. External condylomata were found in 12 of their mothers and in 10 of their fathers. Ten mothers, including two without external lesions, had cervical condylomata. Blot hybridization studies disclosed a genital human papillomavirus (HPV) in 14 of 27 children (HPV-6 in 12 and HPV-11 in two) and in 8 of 14 patients (HPV-6 in all). HPV-6 was found in another child by the polymerase chain reaction technique. Infection occurred most likely at birth or from nonsexual contact, but sexual abuse could not be excluded in one 11-year-old girl. Cutaneous HPV-2 was found in seven children and as yet uncharacterized papillomaviruses were found in two children. Three mothers of HPV-2-infected children had common hand warts, and two children had subungual warts. This study shows the frequent nonsexual transmission of genital papillomaviruses in children and the unexpectedly high association of children's condylomata with papillomaviruses responsible for skin warts, possibly transmitted by heteroinoculation or autoinoculation.
为了确定与儿童尖锐湿疣相关的乳头瘤病毒类型并评估其传播方式，我们研究了32例患有肛门生殖器疣的儿童。在他们的12位母亲和10位父亲身上发现了外生性湿疣。10位母亲，包括2位无外部病变者，患有宫颈湿疣。印迹杂交研究在27例儿童中的14例（12例为HPV-6，2例为HPV-11）以及14例患者中的8例（均为HPV-6）检测到生殖器人乳头瘤病毒（HPV）。通过聚合酶链反应技术在另一名儿童中发现了HPV-6。感染最有可能发生在出生时或通过非性接触，但一名11岁女孩不能排除性虐待的可能。在7例儿童中发现了皮肤型HPV-2，在2例儿童中发现了尚未鉴定的乳头瘤病毒。HPV-2感染儿童的3位母亲患有寻常疣，2例儿童患有甲下疣。本研究表明儿童生殖器乳头瘤病毒常通过非性传播，且儿童尖锐湿疣与引起皮肤疣的乳头瘤病毒意外地高度相关，可能通过异体接种或自体接种传播。
