Division of General Internal Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina,
University of Colorado Anschutz Medical Campus, Denver, Colorado.
WMJ. 2020 Dec;119(4):253-257.
Significant weight loss improves health but regain is common.
The objective of the study was to determine if 2,346 members of Take Off Pounds Sensibly-a national, low-cost, peer-led weight-loss program-achieved and maintained significant weight loss with 7 consecutive annual renewals.
This study was a retrospective cohort design. For each renewal, the cumulative change from baseline weight was calculated. Weight change was placed into 1 of 3 categories: significant weight loss, loss ≥ 5%; weight stable, loss of 0 to < 5%; or weight gain, any amount above baseline weight.
The cohort included 2,346 individuals. Fifty-one percent (n=740) of participants were in the significant weight-loss category all 7 years; 256 (18%) were in the significant weight-loss category at year 1 but moved into at least 1 other category during years 2 through 6; 359 (25%) were in the weight stable category at year 1; and 98 (7%) were in the weight gain category at year 1.
Over 60% of the population achieved significant weight loss by year 7. Since continuous, long-term engagement in a weight-loss program can lead to significant weight loss, even if significant weight loss is not initially achieved, participation should be encouraged.
显著的体重减轻可以改善健康状况，但体重反弹很常见。
本研究的目的是确定 2346 名参加明智减肥计划（Take Off Pounds Sensibly）的成员是否通过连续 7 年的年度续约实现并维持了显著的体重减轻，明智减肥计划是一个全国性的、低成本的、以同伴为领导的减肥项目。
本研究采用回顾性队列设计。对于每次续约，从基线体重计算累计体重变化。体重变化分为以下 3 类之一：显著体重减轻，减轻≥5%；体重稳定，减轻 0 至 <5%；或体重增加，任何超过基线体重的量。
该队列包括 2346 人。51%（n=740）的参与者在所有 7 年均处于显著体重减轻类别；256 人（18%）在第 1 年处于显著体重减轻类别，但在第 2 年至第 6 年期间至少进入了另一个类别；359 人（25%）在第 1 年处于体重稳定类别；98 人（7%）在第 1 年处于体重增加类别。
超过 60%的人群在第 7 年实现了显著的体重减轻。由于持续、长期参与减肥计划可以导致显著的体重减轻，即使最初没有达到显著的体重减轻，也应该鼓励参与。
