Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE 68198, USA.
Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, NE 68198, USA.
Adv Drug Deliv Rev. 2021 Apr;171:215-239. doi: 10.1016/j.addr.2021.01.002. Epub 2021 Jan 9.
The SARS-CoV-2 global pandemic has seen rapid spread, disease morbidities and death associated with substantive social, economic and societal impacts. Treatments rely on re-purposed antivirals and immune modulatory agents focusing on attenuating the acute respiratory distress syndrome. No curative therapies exist. Vaccines remain the best hope for disease control and the principal global effort to end the pandemic. Herein, we summarize those developments with a focus on the role played by nanocarrier delivery.
SARS-CoV-2 全球大流行迅速蔓延，与疾病发病率和死亡率相关的是重大的社会、经济和社会影响。治疗依赖于重新定位的抗病毒药物和免疫调节剂，重点是减轻急性呼吸窘迫综合征。目前还没有治愈疗法。疫苗仍然是控制疾病的最佳希望，也是全球结束大流行的主要努力。在此，我们总结了这些进展，重点介绍了纳米载体传递所发挥的作用。
