Dheyab Mohammed Ali, Aziz Azlan Abdul, Khaniabadi Pegah Moradi, Jameel Mahmood S
Nano-Biotechnology Research and Innovation (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia; Nano-Optoelectronics Research and Technology Lab (NORLab), School of Physics, Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia.
Department of Radiology and Molecular Imaging, College of Medicine and Health Science, Sultan Qaboos University. PO. Box: 35, 123, Al Khod, Muscat, Oman.
Photodiagnosis Photodyn Ther. 2021 Mar;33:102177. doi: 10.1016/j.pdpdt.2021.102177. Epub 2021 Jan 8.
The production of nanomaterials integrating diagnostic and therapeutic roles within one nanoplatform is important for medical applications. Such theranostics nanoplatforms could provide information on imaging, accurate diagnosis and, at the same time, could eradicate cancer cells. FeO@Au core@shell nanoparticles (FeO@AuNPs) have gained broad attention due to their unique innovations in magnetic resonance imaging (MRI) and photothermal therapy (PTT). Seed-mediated growth procedures were used to produce the FeO@AuNPs. In these processes, complicated surface modifications, resulted in unsatisfactory properties. This work used the ability of the sonochemical approach to synthesize highly efficient theranostics agent FeO@AuNPs with a size of approximately 22 nm in 5 min. The inner core of FeO acts as an MRI agent, whereas the photothermal effect stands accomplished by near-infrared absorption of the gold shell (Au shell), which results in the eradication of cancer cells. We have shown that FeO@AuNPs have great biocompatibility and no major cytotoxicity has been identified. Relaxivity value (r) of synthesized FeO@Au NPs, measured at 233 mMs, is significantly higher than those reported previously. The as-synthesized NPs have shown substantial photothermal ablation ability on MCF-7 in vitro under near-infrared laser irradiation. Consequently, FeO@AuNPs synthesized in this study have great potential as an ideal candidate for MR imaging and PTT.
在一个纳米平台上集成诊断和治疗功能的纳米材料的制备对医学应用至关重要。这种诊疗纳米平台能够提供成像信息、实现准确诊断，同时还能根除癌细胞。FeO@Au核壳纳米粒子（FeO@AuNPs）因其在磁共振成像（MRI）和光热疗法（PTT）方面的独特创新而受到广泛关注。采用种子介导生长法制备FeO@AuNPs。在这些过程中，复杂的表面修饰导致性能不尽人意。本研究利用声化学方法的能力，在5分钟内合成了尺寸约为22nm的高效诊疗剂FeO@AuNPs。FeO内核作为MRI剂，而光热效应则通过金壳（Au壳）的近红外吸收来实现，从而根除癌细胞。我们已经证明FeO@AuNPs具有良好的生物相容性，未发现明显的细胞毒性。在233mM下测量的合成FeO@Au NPs的弛豫率值（r）显著高于先前报道的值。合成的纳米粒子在近红外激光照射下对体外MCF-7细胞显示出显著的光热消融能力。因此，本研究中合成的FeO@AuNPs作为MR成像和PTT的理想候选物具有巨大潜力。
