Jameel Mahmood S, Wahab Habibah A, Dheyab Mohammed Ali, Alkatib Huda Hisham Sultan, Ahmad Waqas
Pharmaceutical Design and Simulation Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, 11800, Pulau Pinang, Malaysia.
School of Physics, Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia.
Photochem Photobiol Sci. 2025 Aug 15. doi: 10.1007/s43630-024-00657-9.
Cancer continues to pose a substantial global health challenge, driving the need for new and innovative therapeutic strategies. Among these, photothermal therapy (PTT) has gained attention for its potential. This approach utilizes nanoparticles (NPs) to selectively target and destroy cancer cells, presenting a promising avenue for treatment. This study introduces a rapid, one pot and green synthesis method for synthesizing stable and biocompatible gold nanoparticles (AuNPs) using quercetin, a naturally occurring flavonoid, as both a reducing and stabilizing agent. The sonochemical synthesis of AuNPs employing quercetin not only ensures efficient synthesis but also enhances their stability and biocompatibility, critical for effective PTT against cancer cells. Fourier transform infrared analysis reveals molecular interactions between quercetin and AuNPs, elucidating their conjugation and functionalization. Furthermore, cytotoxicity assays demonstrate the biocompatibility of the synthesized AuNPs, encouraging further investigation into their photothermal efficacy. In vitro photothermal ablation experiments demonstrate the potential of quercetin-mediated AuNPs to induce photoinduced thermal damage to cancer cells under near-infrared laser irradiation. The study also reports a negative zeta potential value (- 35 mV) for the synthesized AuNPs, indicating adequate colloidal stability, and TEM analysis reveals spherical nanoparticles with an average size ranging from 19 to 25 nm. This study presents a simple yet impactful approach for synthesizing AuNPs with enhanced stability and biocompatibility, paving the way for advanced applications in cancer therapy.
癌症仍然是一项重大的全球健康挑战，这推动了对新型创新治疗策略的需求。其中，光热疗法（PTT）因其潜力而受到关注。这种方法利用纳米颗粒（NPs）选择性地靶向并破坏癌细胞，为治疗提供了一条有前景的途径。本研究介绍了一种快速、一锅法且绿色的合成方法，使用天然存在的黄酮类化合物槲皮素作为还原剂和稳定剂来合成稳定且生物相容的金纳米颗粒（AuNPs）。采用槲皮素进行AuNPs的声化学合成不仅确保了高效合成，还增强了它们的稳定性和生物相容性，这对于有效对抗癌细胞的PTT至关重要。傅里叶变换红外分析揭示了槲皮素与AuNPs之间的分子相互作用，阐明了它们的共轭和功能化。此外，细胞毒性试验证明了合成的AuNPs的生物相容性，鼓励进一步研究它们的光热疗效。体外光热消融实验证明了槲皮素介导的AuNPs在近红外激光照射下诱导对癌细胞的光致热损伤的潜力。该研究还报告了合成的AuNPs的负zeta电位值（-35 mV），表明其具有足够的胶体稳定性，并且透射电子显微镜分析揭示了平均尺寸在19至25 nm范围内的球形纳米颗粒。本研究提出了一种简单而有效的方法来合成具有增强稳定性和生物相容性的AuNPs，为癌症治疗的先进应用铺平了道路。
