蛇毒毒素——I. 来自盾鼻蛇（盾鼻蛇或盾鼻蝰蛇）毒液的长链神经毒素S4C6的一级结构。

Snake venom toxins--I. The primary structure of a long neurotoxin S4C6 from Aspidelaps scutatus (shield or shield-nose snake) venom.

Joubert F J

National Chemical Research Laboratory, Council for Scientific and Industrial Research, Pretoria, Republic of South Africa.

Int J Biochem. 1988;20(1):93-6. doi: 10.1016/0020-711x(88)90016-x.

Abstract

Long neurotoxin S4C6 from Aspidelaps scutatus venom was purified by gel filtration and ion exchange chromatography (Joubert, 1987). 2. It contains 68 amino acids including 10 half-cystines. The toxicity of toxin S4C6 was determined and a LD50 of 0.13 +/- 0.04 micrograms/g mouse was found. 3. The complete primary structure of long neurotoxin S4C6 has been elucidated. In the toxin the 10 structurally invariant amino acids of the neurotoxins and cytoxins and the five functionally invariant amino acids of the neurotoxins are conserved.

摘要

来自盾鼻眼镜蛇毒液的长神经毒素S4C6通过凝胶过滤和离子交换色谱法进行了纯化（朱伯特，1987年）。2. 它含有68个氨基酸，包括10个半胱氨酸。测定了毒素S4C6的毒性，发现其对小鼠的半数致死量为0.13±0.04微克/克。3. 长神经毒素S4C6的完整一级结构已被阐明。在该毒素中，神经毒素和细胞毒素的10个结构不变氨基酸以及神经毒素的5个功能不变氨基酸是保守的。