Choi Moonhyun, Heo Jiwoong, Yang Miso, Hong Jinkee
School of Chemical Engineering and Material Science, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea.
ACS Biomater Sci Eng. 2017 Jun 12;3(6):870-874. doi: 10.1021/acsbiomaterials.7b00138. Epub 2017 Apr 28.
Thin films including biocompatible polymers and biological materials as building blocks can be produced with a variety of critical film characteristics, including various materials, thicknesses, roughnesses, amounts of compound released, and release rates for biomedical purposes. We developed a multilayer fabrication system via high-throughput layer-by-layer (LbL) assembly of a nanofilm with inkjet printing to facilitate practical biomedical applications. Our system was used to generate biomolecule (ovalbumin and basic fibroblast growth factor)-containing printed LbL films. This is the first demonstration of the clinical benefits of nanofilm-type nanobiomaterials based on molecular organization, suggesting that novel therapeutic human skin patches could be realized without the need for conventional surgical practices.
以生物相容性聚合物和生物材料为构建单元的薄膜可通过多种关键薄膜特性来制备，这些特性包括用于生物医学目的的各种材料、厚度、粗糙度、化合物释放量和释放速率。我们通过使用喷墨打印对纳米薄膜进行高通量逐层（LbL）组装，开发了一种多层制造系统，以促进实际的生物医学应用。我们的系统用于生成含生物分子（卵清蛋白和碱性成纤维细胞生长因子）的印刷LbL薄膜。这是基于分子组织的纳米薄膜型纳米生物材料临床益处的首次证明，表明无需传统外科手术即可实现新型治疗性人类皮肤贴片。
