Wang Shanshan, Li Chengyi, Meng Ying, Qian Min, Jiang Huiling, Du Yilin, Huang Rongqin, Wang Yi
Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, China.
Center for Advanced Low-dimension Materials, Donghua University, Shanghai 201620, China.
ACS Biomater Sci Eng. 2017 Aug 14;3(8):1702-1709. doi: 10.1021/acsbiomaterials.7b00326. Epub 2017 Jul 18.
Integrating multiple discrete function-related theranostic modalities into one platform for effective cancer treatments has been considered to be a challenge for current nanomedicine design. In this work, a "four-in-one" theranostic system was simply prepared and developed for photoacoustic (PA) imaging-guided synergistic targeting chemo-gene-thermo trimodal therapy of breast cancer. In this system, polyethylene glycol (PEG)-bridged polyethylenimine (PEI) and a memHsp70 receptor-targeting peptide (TKD), PPT, was uniformly capped on doxorubicin (DOX)-loaded oxidized mesoporous carbon nanospheres (OMCN) to encapsulate therapeutic genes into cancer cells via active targeting accumulation. Taking both the advantages of OMCN (high photothermal conversion, strong PA contrast, and controllable drug loading) and the hydrophilic polymer (gene vector, switchable pores' cap, and targeting ability), the "four-in-one" theranostic system exhibited distinct PA imaging visualization, NIR/pH sensitive drug/gene release, and synergistic targeting therapeutic outcome, which were much superior than the single therapy or the combination of two treatments.
将多种与离散功能相关的诊疗模式整合到一个平台以实现有效的癌症治疗，被认为是当前纳米医学设计面临的一项挑战。在这项工作中，我们简单地制备并开发了一种“四合一”诊疗系统，用于光声（PA）成像引导的乳腺癌协同靶向化学-基因-热三模态治疗。在该系统中，聚乙二醇（PEG）桥连的聚乙烯亚胺（PEI）和一种靶向膜Hsp70受体的肽（TKD），即PPT，被均匀地包覆在负载阿霉素（DOX）的氧化介孔碳纳米球（OMCN）上，通过主动靶向积累将治疗基因封装到癌细胞中。兼具OMCN（高光热转换、强PA对比度和可控药物负载）和亲水聚合物（基因载体、可切换孔帽和靶向能力）的优势，“四合一”诊疗系统展现出独特的PA成像可视化、近红外/ pH敏感药物/基因释放以及协同靶向治疗效果，这比单一疗法或两种治疗方法的联合治疗要优越得多。
