Zhang Jinfeng, Zhang Jun, Li Wenyue, Chen Rui, Zhang Zhenyu, Zhang Wenjun, Tang Yongbing, Chen Xiaoyuan, Liu Gang, Lee Chun-Sing
Center of Super-Diamond and Advanced Films (COSDAF) & Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, P. R. China.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, P. R. China.
Theranostics. 2017 Jul 22;7(12):3007-3020. doi: 10.7150/thno.18460. eCollection 2017.
The development of nanoscaled theranostic agents for cancer combination therapies has received intensive attention in recent years. In this report, a degradable hollow mesoporous PEG-Si/C-DOX NP is designed and fabricated for pH-responsive, photoacoustic imaging-guided highly effective chemo-thermal combination therapy. The intrinsic hollow mesoporous structure endows the as-synthesized nanoparticles (NPs) with a high drug loading capacity (31.1%). Under NIR (808 nm) irradiation, the photothermal conversion efficiency of the Si/C NPs is as high as 40.7%. Preferential accumulation of the PEG-Si/C-DOX NPs around tumor tissue was demonstrated with photoacoustic images. Cellular internalization of the NPs and release of the DOX in nuclei are shown with fluorescent images. With efficient NIR photothermal conversion and high DOX loading capacity, the PEG-Si/C-DOX NPs are demonstrated to have remarkable cancer-cell-killing ability and to achieve complete in vivo tumor elimination via combinational chemo-thermal therapy. Last but not least, the NPs show good biodegradability and biosafety, making them a promising candidate for multifunctional drug delivery and cancer theranostic.
近年来，用于癌症联合治疗的纳米级诊疗试剂的研发受到了广泛关注。在本报告中，设计并制备了一种可降解的中空介孔PEG-Si/C-DOX纳米粒子，用于pH响应、光声成像引导的高效化疗-热疗联合治疗。其固有的中空介孔结构赋予了合成后的纳米粒子（NPs）较高的载药能力（31.1%）。在近红外（808 nm）照射下，Si/C NPs的光热转换效率高达40.7%。光声图像显示了PEG-Si/C-DOX NPs在肿瘤组织周围的优先聚集。荧光图像展示了NPs的细胞内化以及阿霉素在细胞核中的释放。凭借高效的近红外光热转换和高阿霉素载药能力，PEG-Si/C-DOX NPs被证明具有显著的癌细胞杀伤能力，并通过联合化疗-热疗实现了体内肿瘤的完全消除。最后但同样重要的是，这些NPs具有良好的生物降解性和生物安全性，使其成为多功能药物递送和癌症诊疗的有前景的候选者。
