Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, China.
School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai, China.
Drug Deliv. 2022 Dec;29(1):1947-1952. doi: 10.1080/10717544.2022.2089298.
Ovarian cancer remains one of serious hazards to human health due to many drawbacks of existing available treatment options. In this study, a multifunctional chemo-thermo combined therapy nanoplatform (OMCNPID) was successfully prepared, which is composed of IP peptide as a targeting moiety to interleukin-6 receptors (IL-6Rs), oxidized mesoporous carbon nanospheres (OMCN) as a near infrared (NIR)-triggered drug carrier and doxorubicin (DOX) as a chemotherapeutic drug and fluorescent agent. The synthesized multifunctional nanoplatform displayed high storage capacity for drugs and excellent photothermal properties. Besides, DOX was rapidly released from OMCNPID at the condition of low pH and NIR laser irradiation due to the dissociation of DOX from graphitic cores of OMCN. experimental results verified that OMCNPID could be markedly taken up by SKOV-3 monolayer cells and tumor spheroids, and revealed a remarkable synergistic chemo-photothermal effect against ovarian cancer. All the results demonstrated that OMCNPID is a pH/NIR dual-stimulus responsive nanoplatform and can achieve efficient chemo-thermo combined therapy.
卵巢癌仍然是人类健康的严重危害之一，这是由于现有治疗方案存在许多缺点。在这项研究中，成功制备了一种多功能化疗-热联合治疗纳米平台（OMCNPID），它由 IP 肽作为靶向部分、白细胞介素-6 受体（IL-6Rs）、氧化介孔碳纳米球（OMCN）作为近红外（NIR）触发药物载体和阿霉素（DOX）作为化疗药物和荧光剂组成。合成的多功能纳米平台表现出对药物的高存储容量和优异的光热性能。此外，由于 DOX 从 OMCN 的石墨核中解离，OMCNPID 在低 pH 值和 NIR 激光照射条件下迅速释放 DOX。实验结果证实，OMCNPID 可以被 SKOV-3 单层细胞和肿瘤球体显著摄取，并对卵巢癌表现出显著的协同化疗-光热效应。所有结果表明，OMCNPID 是一种 pH/NIR 双重刺激响应纳米平台，可以实现高效的化疗-热联合治疗。
