Plastic Surgery, Wuhan Third Hospital, Wuhan.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.
Medicine (Baltimore). 2021 Jan 8;100(1):e23034. doi: 10.1097/MD.0000000000023034.
Botulinum toxin A injection is an established method of treatment. Clinical practitioners use it widely in their practice to prevent the occurrence of facial scars. However, the effectiveness and safeness of has not been comprehensively established. The objective of the current systematic review is to evaluate the efficacy and safety of using botulinum toxin A injection to improve facial scars.
This systematic review involves browsing a number of electronic databases to search for related articles. The search will include databases in both English (PubMed, EMBASE, Web of Science, Spocus, and Cochrane Central Register of Controlled Trials) and Chinese (WanFang database, China Nation Knowledge Infrastructure, and VIP database), the periods of searching will be from inception till the 15th of September 2020. Completing the search in databases allows to consider randomized controlled studies that compares botulinum toxin A interventions to any comparison interventions in those who have facial scars. The review will be inclusive of papers in both languages, English and Chinese. The independent screening of studies for eligibility is conducted by 2 independent authors. Discussion was used to resolve discrepancies between the authors. The Cochrane Risk of Bias Tool V.2.0 is adopted for evaluating the methodological quality of each study. Data extraction was performed by 2 independent authors. For dichotomous outcomes, the were expressed as relative risk (RR) with 95% confidence intervals (CI). For continuous outcomes the results were expressed as the mean difference (MD) or standardized mean difference (SMD) with 95% CI. The statistical analysis of the present study is carried out in RevMan 5.3 software.
This study will output a comprehensive synthesis of existing evidence in relation to botulinum toxin A. Moreover, the results will also provide an interpretation of the effectiveness and safety of botulinum toxin A.
The present review contributes to the existing body of knowledge by adding more evidence to evaluate if botulinum toxin A is effective and safe to be used as an intervention for improving facial scars.
DOI 10.17605/OSF.IO/94TXP (https://osf.io/94TXP/).
肉毒杆菌毒素 A 注射是一种已确立的治疗方法。临床医生在实践中广泛使用它来预防面部疤痕的发生。然而，其有效性和安全性尚未得到全面证实。本系统评价的目的是评估使用肉毒杆菌毒素 A 注射改善面部疤痕的疗效和安全性。
本系统评价包括浏览多个电子数据库以搜索相关文章。搜索将包括英文数据库（PubMed、EMBASE、Web of Science、Spocus 和 Cochrane 对照试验中心注册）和中文数据库（万方数据库、中国知识基础设施和 VIP 数据库），搜索时间从开始到 2020 年 9 月 15 日。在数据库中完成搜索可以考虑将比较肉毒杆菌毒素 A 干预与面部疤痕患者任何比较干预的随机对照研究。综述将包括英文和中文的论文。由 2 位独立作者进行独立的研究入选标准筛查。通过讨论解决作者之间的分歧。采用 Cochrane 偏倚风险工具 V.2.0 评估每项研究的方法学质量。由 2 位独立作者进行数据提取。对于二分类结局，用相对风险（RR）和 95%置信区间（CI）表示。对于连续性结局，用均数差（MD）或标准化均数差（SMD）和 95%CI 表示。本研究的统计分析在 RevMan 5.3 软件中进行。
本研究将对肉毒杆菌毒素 A 的现有证据进行全面综合。此外，结果还将对肉毒杆菌毒素 A 的有效性和安全性进行解释。
本综述通过增加更多的证据来评估肉毒杆菌毒素 A 是否有效和安全，作为改善面部疤痕的干预措施，为现有知识体系做出了贡献。
OSF 注册号：DOI 10.17605/OSF.IO/94TXP（https://osf.io/94TXP/）。
